Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis

The presentation of human immunodeficiency virus (HIV)-associated Hodgkin lymphoma can differ from that of the general population. More specifically, primary bone marrow Hodgkin lymphoma is an uncommon presentation that is more often reported in patients with HIV. Given the many overlapping symptoms...

Descripción completa

Detalles Bibliográficos
Autores principales: Lin, Ji, George, Binsah
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498763/
https://www.ncbi.nlm.nih.gov/pubmed/36140777
http://dx.doi.org/10.3390/genes13091608
_version_ 1784794840862556160
author Lin, Ji
George, Binsah
author_facet Lin, Ji
George, Binsah
author_sort Lin, Ji
collection PubMed
description The presentation of human immunodeficiency virus (HIV)-associated Hodgkin lymphoma can differ from that of the general population. More specifically, primary bone marrow Hodgkin lymphoma is an uncommon presentation that is more often reported in patients with HIV. Given the many overlapping symptoms of Hodgkin lymphoma and HIV as well as HIV-associated infections, diagnosis can be difficult and delayed. We describe a case of primary bone marrow HIV-associated Hodgkin lymphoma complicated by hemophagocytic lymphohistiocytosis (HLH) where the initial work-up was inconclusive. Our case demonstrates the importance of early consideration of HLH as well as the need for an early bone marrow biopsy in a cytopenic patient with a fever of unknown origin.
format Online
Article
Text
id pubmed-9498763
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94987632022-09-23 Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis Lin, Ji George, Binsah Genes (Basel) Case Report The presentation of human immunodeficiency virus (HIV)-associated Hodgkin lymphoma can differ from that of the general population. More specifically, primary bone marrow Hodgkin lymphoma is an uncommon presentation that is more often reported in patients with HIV. Given the many overlapping symptoms of Hodgkin lymphoma and HIV as well as HIV-associated infections, diagnosis can be difficult and delayed. We describe a case of primary bone marrow HIV-associated Hodgkin lymphoma complicated by hemophagocytic lymphohistiocytosis (HLH) where the initial work-up was inconclusive. Our case demonstrates the importance of early consideration of HLH as well as the need for an early bone marrow biopsy in a cytopenic patient with a fever of unknown origin. MDPI 2022-09-08 /pmc/articles/PMC9498763/ /pubmed/36140777 http://dx.doi.org/10.3390/genes13091608 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Case Report
Lin, Ji
George, Binsah
Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
title Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
title_full Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
title_fullStr Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
title_full_unstemmed Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
title_short Primary Bone Marrow HIV-Associated Hodgkin Lymphoma Complicated by Hemophagocytic Lymphohistiocytosis
title_sort primary bone marrow hiv-associated hodgkin lymphoma complicated by hemophagocytic lymphohistiocytosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498763/
https://www.ncbi.nlm.nih.gov/pubmed/36140777
http://dx.doi.org/10.3390/genes13091608
work_keys_str_mv AT linji primarybonemarrowhivassociatedhodgkinlymphomacomplicatedbyhemophagocyticlymphohistiocytosis
AT georgebinsah primarybonemarrowhivassociatedhodgkinlymphomacomplicatedbyhemophagocyticlymphohistiocytosis

Ejemplares similares