Cargando…

The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets

Breast cancer (BC) mortality is almost exclusively due to metastasis, which is the least understood aspect of cancer biology and represents a significant clinical challenge. Although we have witnessed tremendous advancements in the treatment for metastatic breast cancer (mBC), treatment resistance i...

Descripción completa

Detalles Bibliográficos
Autores principales: Yang, Guang, Lu, Tao, Weisenberger, Daniel J., Liang, Gangning
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498783/
https://www.ncbi.nlm.nih.gov/pubmed/36140723
http://dx.doi.org/10.3390/genes13091555
_version_ 1784794845867409408
author Yang, Guang
Lu, Tao
Weisenberger, Daniel J.
Liang, Gangning
author_facet Yang, Guang
Lu, Tao
Weisenberger, Daniel J.
Liang, Gangning
author_sort Yang, Guang
collection PubMed
description Breast cancer (BC) mortality is almost exclusively due to metastasis, which is the least understood aspect of cancer biology and represents a significant clinical challenge. Although we have witnessed tremendous advancements in the treatment for metastatic breast cancer (mBC), treatment resistance inevitably occurs in most patients. Recently, efforts in characterizing mBC revealed distinctive genomic, epigenomic and transcriptomic (multi-omic) landscapes to that of the primary tumor. Understanding of the molecular underpinnings of mBC is key to understanding resistance to therapy and the development of novel treatment options. This review summarizes the differential molecular landscapes of BC and mBC, provides insights into the genomic heterogeneity of mBC and highlights the therapeutically relevant, multi-omic features that may serve as novel therapeutic targets for mBC patients.
format Online
Article
Text
id pubmed-9498783
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-94987832022-09-23 The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets Yang, Guang Lu, Tao Weisenberger, Daniel J. Liang, Gangning Genes (Basel) Review Breast cancer (BC) mortality is almost exclusively due to metastasis, which is the least understood aspect of cancer biology and represents a significant clinical challenge. Although we have witnessed tremendous advancements in the treatment for metastatic breast cancer (mBC), treatment resistance inevitably occurs in most patients. Recently, efforts in characterizing mBC revealed distinctive genomic, epigenomic and transcriptomic (multi-omic) landscapes to that of the primary tumor. Understanding of the molecular underpinnings of mBC is key to understanding resistance to therapy and the development of novel treatment options. This review summarizes the differential molecular landscapes of BC and mBC, provides insights into the genomic heterogeneity of mBC and highlights the therapeutically relevant, multi-omic features that may serve as novel therapeutic targets for mBC patients. MDPI 2022-08-29 /pmc/articles/PMC9498783/ /pubmed/36140723 http://dx.doi.org/10.3390/genes13091555 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Yang, Guang
Lu, Tao
Weisenberger, Daniel J.
Liang, Gangning
The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
title The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
title_full The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
title_fullStr The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
title_full_unstemmed The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
title_short The Multi-Omic Landscape of Primary Breast Tumors and Their Metastases: Expanding the Efficacy of Actionable Therapeutic Targets
title_sort multi-omic landscape of primary breast tumors and their metastases: expanding the efficacy of actionable therapeutic targets
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498783/
https://www.ncbi.nlm.nih.gov/pubmed/36140723
http://dx.doi.org/10.3390/genes13091555
work_keys_str_mv AT yangguang themultiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT lutao themultiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT weisenbergerdanielj themultiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT lianggangning themultiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT yangguang multiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT lutao multiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT weisenbergerdanielj multiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets
AT lianggangning multiomiclandscapeofprimarybreasttumorsandtheirmetastasesexpandingtheefficacyofactionabletherapeutictargets