Cargando…
Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure
Craniospinal irradiation (CSI) is a complex radiation technique employed to treat patients with primitive neuroectodermal tumors such as medulloblastoma or germinative brain tumors with the risk of leptomeningeal spread. In adults, this technique poses a technically challenging planning process beca...
Autores principales: | , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498794/ https://www.ncbi.nlm.nih.gov/pubmed/36135294 http://dx.doi.org/10.3390/gels8090582 |
_version_ | 1784794848660815872 |
---|---|
author | da Silveira, Matheus Antonio Pavoni, Juliana Fernandes Bruno, Alexandre Colello Arruda, Gustavo Viani Baffa, Oswaldo |
author_facet | da Silveira, Matheus Antonio Pavoni, Juliana Fernandes Bruno, Alexandre Colello Arruda, Gustavo Viani Baffa, Oswaldo |
author_sort | da Silveira, Matheus Antonio |
collection | PubMed |
description | Craniospinal irradiation (CSI) is a complex radiation technique employed to treat patients with primitive neuroectodermal tumors such as medulloblastoma or germinative brain tumors with the risk of leptomeningeal spread. In adults, this technique poses a technically challenging planning process because of the complex shape and length of the target volume. Thus, it requires multiple fields and different isocenters to guarantee the primary-tumor dose delivery. Recently, some authors have proposed the use IMRT technique for this planning with the possibility of overlapping adjacent fields. The high-dose delivery complexity demands three-dimensional dosimetry (3DD) to verify this irradiation procedure and motivated this study. We used an optical CT and a radiochromic Fricke-xylenol-orange gel with the addition of formaldehyde (FXO-f) to evaluate the doses delivered at the field junction region of this treatment. We found 96.91% as the mean passing rate using the gamma analysis with 3%/2 mm criteria at the junction region. However, the concentration of fail points in a determined region called attention to this evaluation, indicating the advantages of employing a 3DD technique in complex dose-distribution verifications. |
format | Online Article Text |
id | pubmed-9498794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94987942022-09-23 Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure da Silveira, Matheus Antonio Pavoni, Juliana Fernandes Bruno, Alexandre Colello Arruda, Gustavo Viani Baffa, Oswaldo Gels Article Craniospinal irradiation (CSI) is a complex radiation technique employed to treat patients with primitive neuroectodermal tumors such as medulloblastoma or germinative brain tumors with the risk of leptomeningeal spread. In adults, this technique poses a technically challenging planning process because of the complex shape and length of the target volume. Thus, it requires multiple fields and different isocenters to guarantee the primary-tumor dose delivery. Recently, some authors have proposed the use IMRT technique for this planning with the possibility of overlapping adjacent fields. The high-dose delivery complexity demands three-dimensional dosimetry (3DD) to verify this irradiation procedure and motivated this study. We used an optical CT and a radiochromic Fricke-xylenol-orange gel with the addition of formaldehyde (FXO-f) to evaluate the doses delivered at the field junction region of this treatment. We found 96.91% as the mean passing rate using the gamma analysis with 3%/2 mm criteria at the junction region. However, the concentration of fail points in a determined region called attention to this evaluation, indicating the advantages of employing a 3DD technique in complex dose-distribution verifications. MDPI 2022-09-13 /pmc/articles/PMC9498794/ /pubmed/36135294 http://dx.doi.org/10.3390/gels8090582 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Article da Silveira, Matheus Antonio Pavoni, Juliana Fernandes Bruno, Alexandre Colello Arruda, Gustavo Viani Baffa, Oswaldo Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure |
title | Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure |
title_full | Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure |
title_fullStr | Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure |
title_full_unstemmed | Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure |
title_short | Three-Dimensional Dosimetry by Optical-CT and Radiochromic Gel Dosimeter of a Multiple Isocenter Craniospinal Radiation Therapy Procedure |
title_sort | three-dimensional dosimetry by optical-ct and radiochromic gel dosimeter of a multiple isocenter craniospinal radiation therapy procedure |
topic | Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498794/ https://www.ncbi.nlm.nih.gov/pubmed/36135294 http://dx.doi.org/10.3390/gels8090582 |
work_keys_str_mv | AT dasilveiramatheusantonio threedimensionaldosimetrybyopticalctandradiochromicgeldosimeterofamultipleisocentercraniospinalradiationtherapyprocedure AT pavonijulianafernandes threedimensionaldosimetrybyopticalctandradiochromicgeldosimeterofamultipleisocentercraniospinalradiationtherapyprocedure AT brunoalexandrecolello threedimensionaldosimetrybyopticalctandradiochromicgeldosimeterofamultipleisocentercraniospinalradiationtherapyprocedure AT arrudagustavoviani threedimensionaldosimetrybyopticalctandradiochromicgeldosimeterofamultipleisocentercraniospinalradiationtherapyprocedure AT baffaoswaldo threedimensionaldosimetrybyopticalctandradiochromicgeldosimeterofamultipleisocentercraniospinalradiationtherapyprocedure |