Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms

Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from eithe...

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Autores principales: Ito, Sohei, Lu, Hong S., Daugherty, Alan, Sawada, Hisashi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498804/
https://www.ncbi.nlm.nih.gov/pubmed/36140786
http://dx.doi.org/10.3390/genes13091618
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author Ito, Sohei
Lu, Hong S.
Daugherty, Alan
Sawada, Hisashi
author_facet Ito, Sohei
Lu, Hong S.
Daugherty, Alan
Sawada, Hisashi
author_sort Ito, Sohei
collection PubMed
description Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs.
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spelling pubmed-94988042022-09-23 Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms Ito, Sohei Lu, Hong S. Daugherty, Alan Sawada, Hisashi Genes (Basel) Review Smooth muscle cells (SMCs) are the major cell type of the aortic wall and play a pivotal role in the pathophysiology of thoracic aortic aneurysms (TAAs). TAAs occur in a region-specific manner with the proximal region being a common location. In this region, SMCs are derived embryonically from either the cardiac neural crest or the second heart field. These cells of distinct origins reside in specific locations and exhibit different biological behaviors in the complex mechanism of TAAs. The purpose of this review is to enhance understanding of the embryonic heterogeneity of SMCs in the proximal thoracic aorta and their functions in TAAs. MDPI 2022-09-09 /pmc/articles/PMC9498804/ /pubmed/36140786 http://dx.doi.org/10.3390/genes13091618 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ito, Sohei
Lu, Hong S.
Daugherty, Alan
Sawada, Hisashi
Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
title Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
title_full Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
title_fullStr Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
title_full_unstemmed Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
title_short Embryonic Heterogeneity of Smooth Muscle Cells in the Complex Mechanisms of Thoracic Aortic Aneurysms
title_sort embryonic heterogeneity of smooth muscle cells in the complex mechanisms of thoracic aortic aneurysms
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498804/
https://www.ncbi.nlm.nih.gov/pubmed/36140786
http://dx.doi.org/10.3390/genes13091618
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AT daughertyalan embryonicheterogeneityofsmoothmusclecellsinthecomplexmechanismsofthoracicaorticaneurysms
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