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Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture

Diabetes mellitus is associated with prothrombotic states and thrombotic events. This study examined the association between preoperative glucose levels and deep vein thrombosis (DVT) in trauma patients undergoing surgery for lower limb fracture. Data from 1,591 patients who underwent fracture surge...

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Autores principales: Liu, Xiaojie, Li, Tiajun, Xu, Hui, Wang, Chunhua, Ma, Xiaojun, Huang, Hui, Hu, Yanling, Chu, Haichen
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498976/
https://www.ncbi.nlm.nih.gov/pubmed/36158801
http://dx.doi.org/10.3389/fcvm.2022.944506
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author Liu, Xiaojie
Li, Tiajun
Xu, Hui
Wang, Chunhua
Ma, Xiaojun
Huang, Hui
Hu, Yanling
Chu, Haichen
author_facet Liu, Xiaojie
Li, Tiajun
Xu, Hui
Wang, Chunhua
Ma, Xiaojun
Huang, Hui
Hu, Yanling
Chu, Haichen
author_sort Liu, Xiaojie
collection PubMed
description Diabetes mellitus is associated with prothrombotic states and thrombotic events. This study examined the association between preoperative glucose levels and deep vein thrombosis (DVT) in trauma patients undergoing surgery for lower limb fracture. Data from 1,591 patients who underwent fracture surgery between January 2017 and March 2022 at the Affiliated Hospital of Qingdao University were queried from institutional electronic medical records. A total study population of 1,086 patients was identified, comprising 138 patients who experienced DVT and 948 controls. The primary outcome was DVT. Multiple logistic regression analyses were performed and a receiver operating characteristic (ROC) curve was generated. Age, D-dimer level, preoperative RBC count, and preoperative glucose level were independent predictors of DVT. The two highest categories of D-dimer level (≥ 960, < 2,102; ≥ 2,102 ng/ml) increased the odds ratio for DVT by 4.215 times [95% confidence interval (CI) 1.820–9.761] and 7.896 times (95% CI 3.449–18.074), respectively, compared with the lowest reference category (< 490 ng/ml). The area under the curve (AUC) for the preoperative glucose level was 0.605. Hyperglycemia (glucose ≥ 6.1, < 7.0 mmol/l) increased the odds of DVT by 1.889-fold [95% CI (1.085–3.291); p < 0.0001] compared with euglycemia (glucose < 6.1 mmol/l). We therefore observed an association between preoperative hyperglycemia and DVT in patients with lower limb fractures. There are several modalities for controlling hyperglycemia, offering potential targets for future improvement.
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spelling pubmed-94989762022-09-23 Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture Liu, Xiaojie Li, Tiajun Xu, Hui Wang, Chunhua Ma, Xiaojun Huang, Hui Hu, Yanling Chu, Haichen Front Cardiovasc Med Cardiovascular Medicine Diabetes mellitus is associated with prothrombotic states and thrombotic events. This study examined the association between preoperative glucose levels and deep vein thrombosis (DVT) in trauma patients undergoing surgery for lower limb fracture. Data from 1,591 patients who underwent fracture surgery between January 2017 and March 2022 at the Affiliated Hospital of Qingdao University were queried from institutional electronic medical records. A total study population of 1,086 patients was identified, comprising 138 patients who experienced DVT and 948 controls. The primary outcome was DVT. Multiple logistic regression analyses were performed and a receiver operating characteristic (ROC) curve was generated. Age, D-dimer level, preoperative RBC count, and preoperative glucose level were independent predictors of DVT. The two highest categories of D-dimer level (≥ 960, < 2,102; ≥ 2,102 ng/ml) increased the odds ratio for DVT by 4.215 times [95% confidence interval (CI) 1.820–9.761] and 7.896 times (95% CI 3.449–18.074), respectively, compared with the lowest reference category (< 490 ng/ml). The area under the curve (AUC) for the preoperative glucose level was 0.605. Hyperglycemia (glucose ≥ 6.1, < 7.0 mmol/l) increased the odds of DVT by 1.889-fold [95% CI (1.085–3.291); p < 0.0001] compared with euglycemia (glucose < 6.1 mmol/l). We therefore observed an association between preoperative hyperglycemia and DVT in patients with lower limb fractures. There are several modalities for controlling hyperglycemia, offering potential targets for future improvement. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9498976/ /pubmed/36158801 http://dx.doi.org/10.3389/fcvm.2022.944506 Text en Copyright © 2022 Liu, Li, Xu, Wang, Ma, Huang, Hu and Chu. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cardiovascular Medicine
Liu, Xiaojie
Li, Tiajun
Xu, Hui
Wang, Chunhua
Ma, Xiaojun
Huang, Hui
Hu, Yanling
Chu, Haichen
Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
title Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
title_full Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
title_fullStr Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
title_full_unstemmed Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
title_short Hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
title_sort hyperglycemia may increase deep vein thrombosis in trauma patients with lower limb fracture
topic Cardiovascular Medicine
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9498976/
https://www.ncbi.nlm.nih.gov/pubmed/36158801
http://dx.doi.org/10.3389/fcvm.2022.944506
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