Cargando…

Unconventional genetic code systems in archaea

Archaea constitute the third domain of life, distinct from bacteria and eukaryotes given their ability to tolerate extreme environments. To survive these harsh conditions, certain archaeal lineages possess unique genetic code systems to encode either selenocysteine or pyrrolysine, rare amino acids n...

Descripción completa

Detalles Bibliográficos
Autores principales: Meng, Kexin, Chung, Christina Z., Söll, Dieter, Krahn, Natalie
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499178/
https://www.ncbi.nlm.nih.gov/pubmed/36160229
http://dx.doi.org/10.3389/fmicb.2022.1007832
_version_ 1784794936162385920
author Meng, Kexin
Chung, Christina Z.
Söll, Dieter
Krahn, Natalie
author_facet Meng, Kexin
Chung, Christina Z.
Söll, Dieter
Krahn, Natalie
author_sort Meng, Kexin
collection PubMed
description Archaea constitute the third domain of life, distinct from bacteria and eukaryotes given their ability to tolerate extreme environments. To survive these harsh conditions, certain archaeal lineages possess unique genetic code systems to encode either selenocysteine or pyrrolysine, rare amino acids not found in all organisms. Furthermore, archaea utilize alternate tRNA-dependent pathways to biosynthesize and incorporate members of the 20 canonical amino acids. Recent discoveries of new archaeal species have revealed the co-occurrence of these genetic code systems within a single lineage. This review discusses the diverse genetic code systems of archaea, while detailing the associated biochemical elements and molecular mechanisms.
format Online
Article
Text
id pubmed-9499178
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-94991782022-09-23 Unconventional genetic code systems in archaea Meng, Kexin Chung, Christina Z. Söll, Dieter Krahn, Natalie Front Microbiol Microbiology Archaea constitute the third domain of life, distinct from bacteria and eukaryotes given their ability to tolerate extreme environments. To survive these harsh conditions, certain archaeal lineages possess unique genetic code systems to encode either selenocysteine or pyrrolysine, rare amino acids not found in all organisms. Furthermore, archaea utilize alternate tRNA-dependent pathways to biosynthesize and incorporate members of the 20 canonical amino acids. Recent discoveries of new archaeal species have revealed the co-occurrence of these genetic code systems within a single lineage. This review discusses the diverse genetic code systems of archaea, while detailing the associated biochemical elements and molecular mechanisms. Frontiers Media S.A. 2022-09-08 /pmc/articles/PMC9499178/ /pubmed/36160229 http://dx.doi.org/10.3389/fmicb.2022.1007832 Text en Copyright © 2022 Meng, Chung, Söll and Krahn. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Microbiology
Meng, Kexin
Chung, Christina Z.
Söll, Dieter
Krahn, Natalie
Unconventional genetic code systems in archaea
title Unconventional genetic code systems in archaea
title_full Unconventional genetic code systems in archaea
title_fullStr Unconventional genetic code systems in archaea
title_full_unstemmed Unconventional genetic code systems in archaea
title_short Unconventional genetic code systems in archaea
title_sort unconventional genetic code systems in archaea
topic Microbiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499178/
https://www.ncbi.nlm.nih.gov/pubmed/36160229
http://dx.doi.org/10.3389/fmicb.2022.1007832
work_keys_str_mv AT mengkexin unconventionalgeneticcodesystemsinarchaea
AT chungchristinaz unconventionalgeneticcodesystemsinarchaea
AT solldieter unconventionalgeneticcodesystemsinarchaea
AT krahnnatalie unconventionalgeneticcodesystemsinarchaea