Cargando…

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Mostrar otras versiones (1)

SARS-CoV-2 non-structural protein Nsp14 is a highly conserved enzyme necessary for viral replication. Nsp14 forms a stable complex with non-structural protein Nsp10 and exhibits exoribonuclease and N7-methyltransferase activities. Protein-interactome studies identified human sirtuin 5 (SIRT5) as a p...

Descripción completa

Detalles Bibliográficos
Autores principales:	Walter, Marius, Chen, Irene P., Vallejo-Gracia, Albert, Kim, Ik-Jung, Bielska, Olga, Lam, Victor L., Hayashi, Jennifer M., Cruz, Andrew, Shah, Samah, Soveg, Frank W., Gross, John D., Krogan, Nevan J., Jerome, Keith R., Schilling, Birgit, Ott, Melanie, Verdin, Eric
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499238/ https://www.ncbi.nlm.nih.gov/pubmed/36095012 http://dx.doi.org/10.1371/journal.ppat.1010811

Ejemplares similares

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein
por: Walter, Marius, et al.
Publicado: (2022)

Metabolic reprogramming of human CD8(+) memory T cells through loss of SIRT1
por: Jeng, Mark Y., et al.
Publicado: (2018)

Histone malonylation is regulated by SIRT5 and KAT2A
por: Zhang, Ran, et al.
Publicado: (2023)

SARS-CoV-2 nsp13, nsp14, nsp15 and orf6 function as potent interferon antagonists
por: Yuen, Chun-Kit, et al.
Publicado: (2020)

Effects of Mutagenesis of Murine Hepatitis Virus NSP1 and NSP14 on Replication in Culture
por: Eckerle, Lance D., et al.
Publicado: (2006)

Exoribonuclease in nonstructural protein 14 (nsp14-ExoN)
Publicado: (2013)

The NSP14/NSP10 RNA repair complex as a Pan-coronavirus therapeutic target
por: Rona, Gergely, et al.
Publicado: (2021)

Identification of fragments binding to SARS-CoV-2 nsp10 reveals ligand-binding sites in conserved interfaces between nsp10 and nsp14/nsp16
por: Kozielski, Frank, et al.
Publicado: (2021)

Coenzyme A binding sites induce proximal acylation across protein families
por: Carrico, Chris, et al.
Publicado: (2023)

Activation of the SARS-CoV-2 NSP14 3′–5′ exoribonuclease by NSP10 and response to antiviral inhibitors
por: Riccio, Amanda A., et al.
Publicado: (2021)

Discovery of SARS-CoV-2 Nsp14 and Nsp16 Methyltransferase Inhibitors by High-Throughput Virtual Screening
por: Bobrovs, Raitis, et al.
Publicado: (2021)

Exploring the therapeutic nature of limonoids and triterpenoids against SARS-CoV-2 by targeting nsp13, nsp14, and nsp15 through molecular docking and dynamics simulations
por: Vardhan, Seshu, et al.
Publicado: (2021)

Identifying SARS-CoV-2 antiviral compounds by screening for small molecule inhibitors of nsp14/nsp10 exoribonuclease
por: Canal, Berta, et al.
Publicado: (2021)

Refolding of lid subdomain of SARS-CoV-2 nsp14 upon nsp10 interaction releases exonuclease activity
por: Czarna, Anna, et al.
Publicado: (2022)

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication and pathogenesis in vivo
por: Taha, Taha Y., et al.
Publicado: (2023)

T cell stimulation remodels the latently HIV-1 infected cell population by differential activation of proviral chromatin
por: Lindqvist, Birgitta, et al.
Publicado: (2022)

A single inactivating amino acid change in the SARS-CoV-2 NSP3 Mac1 domain attenuates viral replication in vivo
por: Taha, Taha Y., et al.
Publicado: (2023)

Remdesivir and SARS-CoV-2: Structural requirements at both nsp12 RdRp and nsp14 Exonuclease active-sites
por: Shannon, Ashleigh, et al.
Publicado: (2020)

SIRT1 deacetylates RORγt and enhances Th17 cell generation
por: Lim, Hyung W., et al.
Publicado: (2015)

SIRT1 deacetylates RORγt and enhances Th17 cell generation
por: Lim, Hyung W., et al.
Publicado: (2015)

Coronavirus NSP6 protein (nsp6)
Publicado: (2014)

Differential network biology
por: Ideker, Trey, et al.
Publicado: (2012)

Mapping genetic interactions in cancer: a road to rational combination therapies
por: Tutuncuoglu, Beril, et al.
Publicado: (2019)

Label-Free Screening of SARS-CoV-2 NSP14 Exonuclease Activity Using SAMDI Mass Spectrometry
por: Scholle, Michael D., et al.
Publicado: (2021)

SIRT3 controls brown fat thermogenesis by deacetylation regulation of pathways upstream of UCP1
por: Sebaa, Rajaa, et al.
Publicado: (2019)

The human silent information regulator (Sir)2 homologue hSIRT3 is a mitochondrial nicotinamide adenine dinucleotide–dependent deacetylase
por: Schwer, Björn, et al.
Publicado: (2002)

In silico structure modelling of SARS-CoV-2 Nsp13 helicase and Nsp14 and repurposing of FDA approved antiviral drugs as dual inhibitors
por: Gurung, Arun Bahadur
Publicado: (2020)

Interphase Nucleo-Cytoplasmic Shuttling and Localization of SIRT2 during Mitosis
por: North, Brian J., et al.
Publicado: (2007)

Signals and systems
por: Krogan, Nevan J, et al.
Publicado: (2006)

The next frontier of systems biology: higher-order and interspecies interactions
por: Fischbach, Michael A, et al.
Publicado: (2010)

Creating collaboration by breaking down scientific barriers
por: Fabius, Jacqueline M., et al.
Publicado: (2021)

Lessons learned for pandemic preparedness: A collaborative network is imperative
por: Fabius, Jacqueline M., et al.
Publicado: (2023)

SIRT1 and SIRT3 Deacetylate Homologous Substrates: AceCS1,2 and HMGCS1,2
por: Hirschey, Matthew D., et al.
Publicado: (2011)

Structural insights into regulation of the PEAK3 pseudokinase scaffold by 14-3-3
por: Torosyan, Hayarpi, et al.
Publicado: (2023)

Involvement of PRRSV NSP3 and NSP5 in the autophagy process
por: Zhang, Wei, et al.
Publicado: (2019)

Structure of the SARS-CoV nsp12 polymerase bound to nsp7 and nsp8 co-factors
por: Kirchdoerfer, Robert N., et al.
Publicado: (2019)

Transient and stabilized complexes of Nsp7, Nsp8, and Nsp12 in SARS-CoV-2 replication
por: Wilamowski, Mateusz, et al.
Publicado: (2021)

A Yeast Suppressor Screen Used To Identify Mammalian SIRT1 as a Proviral Factor for Middle East Respiratory Syndrome Coronavirus Replication
por: Weston, Stuart, et al.
Publicado: (2019)

Crystal structure of SARS-CoV-2 nsp10 bound to nsp14-ExoN domain reveals an exoribonuclease with both structural and functional integrity
por: Lin, Sheng, et al.
Publicado: (2021)

Characterization of the guanine-N7 methyltransferase activity of coronavirus nsp14 on nucleotide GTP
por: Jin, Xu, et al.
Publicado: (2013)

Cannot write session to /tmp/vufind_sessions/sess_2mubqoeuo3v1lplouchcmdntah