Cargando…

The impact of Mendelian sleep and circadian genetic variants in a population setting

Rare variants in ten genes have been reported to cause Mendelian sleep conditions characterised by extreme sleep duration or timing. These include familial natural short sleep (ADRB1, DEC2/BHLHE41, GRM1 and NPSR1), advanced sleep phase (PER2, PER3, CRY2, CSNK1D and TIMELESS) and delayed sleep phase...

Descripción completa

Detalles Bibliográficos
Autores principales:	Weedon, Michael N., Jones, Samuel E., Lane, Jacqueline M., Lee, Jiwon, Ollila, Hanna M., Dawes, Amy, Tyrrell, Jess, Beaumont, Robin N., Partonen, Timo, Merikanto, Ilona, Rich, Stephen S., Rotter, Jerome I., Frayling, Timothy M., Rutter, Martin K., Redline, Susan, Sofer, Tamar, Saxena, Richa, Wood, Andrew R.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2022
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499244/ https://www.ncbi.nlm.nih.gov/pubmed/36137075 http://dx.doi.org/10.1371/journal.pgen.1010356

Ejemplares similares

Circadian Type Determines Working Ability: Poorer Working Ability in Evening-Types is Mediated by Insufficient Sleep in a Large Population-Based Sample of Working-Age Adults
por: Merikanto, Ilona, et al.
Publicado: (2022)

Higher adiposity and mental health: causal inference using Mendelian randomization
por: Casanova, Francesco, et al.
Publicado: (2021)

Height, body mass index, and socioeconomic status: mendelian randomisation study in UK Biobank
por: Tyrrell, Jessica, et al.
Publicado: (2016)

Genetic evidence that higher central adiposity causes gastro-oesophageal reflux disease: a Mendelian randomization study
por: Green, Harry D, et al.
Publicado: (2020)

Genome-wide association analyses of chronotype in 697,828 individuals provides insights into circadian rhythms
por: Jones, Samuel E., et al.
Publicado: (2019)

Investigating causal relations between sleep traits and risk of breast cancer in women: mendelian randomisation study
por: Richmond, Rebecca C, et al.
Publicado: (2019)

Assessing the Causal Role of Sleep Traits on Glycated Hemoglobin: A Mendelian Randomization Study
por: Liu, Junxi, et al.
Publicado: (2022)

Upregulated heme biosynthesis increases obstructive sleep apnea severity: a pathway-based Mendelian randomization study
por: Wang, Heming, et al.
Publicado: (2022)

Association between sleep disordered breathing and epigenetic age acceleration: Evidence from the Multi-Ethnic Study of Atherosclerosis
por: Li, Xiaoyu, et al.
Publicado: (2019)

Using Mendelian Randomisation methods to understand whether diurnal preference is causally related to mental health
por: O’Loughlin, Jessica, et al.
Publicado: (2021)

Is disrupted sleep a risk factor for Alzheimer’s disease? Evidence from a two-sample Mendelian randomization analysis
por: Anderson, Emma L, et al.
Publicado: (2020)

A genome-wide association study identifies 5 loci associated with frozen shoulder and implicates diabetes as a causal risk factor
por: Green, Harry D., et al.
Publicado: (2021)

Identification and analysis of individuals who deviate from their genetically-predicted phenotype
por: Hawkes, Gareth, et al.
Publicado: (2023)

Identification and analysis of individuals who deviate from their genetically-predicted phenotype
por: Hawkes, Gareth, et al.
Publicado: (2023)

Mendelian randomization supports a causative effect of TSH on thyroid carcinoma
por: Fussey, Jonathan M, et al.
Publicado: (2020)

RETRACTION: Mendelian randomization supports a causative effect of TSH on thyroid carcinoma
por: Fussey, Jonathan M, et al.
Publicado: (2020)

Associations of common chronic non-communicable diseases and medical conditions with sleep-related problems in a population-based health examination study
por: Basnet, Syaron, et al.
Publicado: (2016)

Seasonality, morningness-eveningness, and sleep in common non - communicable medical conditions and chronic diseases in a population
por: Basnet, Syaron, et al.
Publicado: (2018)

Circadian Clock Proteins in Mood Regulation
por: Partonen, Timo
Publicado: (2015)

Effects of body mass index on relationship status, social contact and socio-economic position: Mendelian randomization and within-sibling study in UK Biobank
por: Howe, Laura D, et al.
Publicado: (2019)

Does Obesity Cause Thyroid Cancer? A Mendelian Randomization Study
por: Fussey, Jonathan Mark, et al.
Publicado: (2020)

Chronotype Genetic Variant in PER2 is Associated with Intrinsic Circadian Period in Humans
por: Chang, Anne-Marie, et al.
Publicado: (2019)

Systematic Analysis of Circadian Genes in a Population-Based Sample Reveals Association of TIMELESS with Depression and Sleep Disturbance
por: Utge, Siddheshwar J., et al.
Publicado: (2010)

Genetic evidence that lower circulating FSH levels lengthen menstrual cycle, increase age at menopause and impact female reproductive health
por: Ruth, Katherine S., et al.
Publicado: (2016)

A genome-wide association study implicates multiple mechanisms influencing raised urinary albumin–creatinine ratio
por: Casanova, Francesco, et al.
Publicado: (2019)

Variants in the FTO and CDKAL1 loci have recessive effects on risk of obesity and type 2 diabetes, respectively
por: Wood, Andrew R., et al.
Publicado: (2016)

Behavioral Trait of Morningness-Eveningness in Association with Articular and Spinal Diseases in a Population
por: Merikanto, Ilona, et al.
Publicado: (2014)

Rare genetic variants in genes and loci linked to dominant monogenic developmental disorders cause milder related phenotypes in the general population
por: Kingdom, Rebecca, et al.
Publicado: (2022)

Development and Standardization of an Improved Type 1 Diabetes Genetic Risk Score for Use in Newborn Screening and Incident Diagnosis
por: Sharp, Seth A., et al.
Publicado: (2019)

Portability of Polygenic Risk Scores for Sleep Duration, Insomnia and Chronotype in 33,493 Individuals
por: Perkiö, Anna, et al.
Publicado: (2022)

Mendelian Randomization Analyses Suggest Childhood Body Size Indirectly Influences End Points From Across the Cardiovascular Disease Spectrum Through Adult Body Size
por: Power, Grace M., et al.
Publicado: (2021)

Insights into the genetics of menopausal vasomotor symptoms: genome-wide analyses of routinely-collected primary care health records
por: Ruth, Katherine S., et al.
Publicado: (2023)

Assessing the Pathogenicity, Penetrance, and Expressivity of Putative Disease-Causing Variants in a Population Setting
por: Wright, Caroline F., et al.
Publicado: (2019)

Circadian Rest–Activity Rhythms, Delirium Risk, and Progression to Dementia
por: Gao, Lei, et al.
Publicado: (2023)

Mendelian randomization highlights insomnia as a risk factor for pain diagnoses
por: Broberg, Martin, et al.
Publicado: (2021)

Correlations in sleeping patterns and circadian preference between spouses
por: Richmond, Rebecca C., et al.
Publicado: (2023)

Circadian preference towards morningness is associated with lower slow sleep spindle amplitude and intensity in adolescents
por: Merikanto, Ilona, et al.
Publicado: (2017)

A composite sleep and pulmonary phenotype predicting hypertension
por: Li, Ruitong, et al.
Publicado: (2021)

Publisher Correction: Circadian preference towards morningness is associated with lower slow sleep spindle amplitude and intensity in adolescents
por: Merikanto, Ilona, et al.
Publicado: (2018)

Association of maternal circulating 25(OH)D and calcium with birth weight: A mendelian randomisation analysis
por: Thompson, William D., et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_nams0g0smrqulhkg0qpalpmt3q