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Objective and subjective measures of sleep in men with Muscular Dystrophy
PURPOSE: Despite poor sleep quality being recognised in Duchenne Muscular Dystrophy, reports from milder forms of Muscular Dystrophy (MD), and accompanied associations with quality of life (QoL), pain and fatigue, remain limited however. METHODS: Adult males (n = 15 Beckers MD (BMD), n = 12 Limb-Gir...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499246/ https://www.ncbi.nlm.nih.gov/pubmed/36137167 http://dx.doi.org/10.1371/journal.pone.0274970 |
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author | Morse, Christopher I. Onambele-Pearson, Gladys Edwards, Bryn Wong, Sze Choong Jacques, Matthew F. |
author_facet | Morse, Christopher I. Onambele-Pearson, Gladys Edwards, Bryn Wong, Sze Choong Jacques, Matthew F. |
author_sort | Morse, Christopher I. |
collection | PubMed |
description | PURPOSE: Despite poor sleep quality being recognised in Duchenne Muscular Dystrophy, reports from milder forms of Muscular Dystrophy (MD), and accompanied associations with quality of life (QoL), pain and fatigue, remain limited however. METHODS: Adult males (n = 15 Beckers MD (BMD), n = 12 Limb-Girdle MD (LGMD), n = 12 Fascioscapulohumeral (FSHD), n = 14 non-MD (CTRL)) completed assessments of body composition (Bio-electrical impedance), sleep (7-day 24-hour tri-axial accelerometer, Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index, QoL (SF36-v2), pain (Visual analogue scale), fatigue (Modified Fatigue Index Scale) and functional assessments (Brookes and Vignos). RESULTS: FSHD and BMD reported worse sleep than CTRL on the PSQI. FSHD scored worse than CTRL on the Insomnia Severity Index (P<0.05). 25–63% and 50–81% of adults with MD reported poor sleep quality using the Insomnia Severity Index and PSQI, respectively. Accelerometery identified no difference in sleep quality between groups. Associations were identified between sleep measures (PSQI global and insomnia severity) with mental or physical QoL in LGMD, BMD and FSHD. Multiple regression identified associations between sleep impairment and fatigue severity (all MDs), body composition (BMD & LGMD), upper and lower limb function (LGMD, FSHD) and age (FSHD). CONCLUSIONS: 25–81% of men with MD, depending on classification, experience sleep impairment, using self-report sleep measures. Whilst BMD and FSHD showed worse sleep outcomes than CTRL, no group difference was observed between LGMD and CTRL, however all groups showed associations with sleep impairment and higher levels of fatigue. These findings, and associations with measures of health and wellbeing, highlight an area for further research which could impact QoL in adults with MD. |
format | Online Article Text |
id | pubmed-9499246 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94992462022-09-23 Objective and subjective measures of sleep in men with Muscular Dystrophy Morse, Christopher I. Onambele-Pearson, Gladys Edwards, Bryn Wong, Sze Choong Jacques, Matthew F. PLoS One Research Article PURPOSE: Despite poor sleep quality being recognised in Duchenne Muscular Dystrophy, reports from milder forms of Muscular Dystrophy (MD), and accompanied associations with quality of life (QoL), pain and fatigue, remain limited however. METHODS: Adult males (n = 15 Beckers MD (BMD), n = 12 Limb-Girdle MD (LGMD), n = 12 Fascioscapulohumeral (FSHD), n = 14 non-MD (CTRL)) completed assessments of body composition (Bio-electrical impedance), sleep (7-day 24-hour tri-axial accelerometer, Pittsburgh Sleep Quality Index (PSQI) and Insomnia Severity Index, QoL (SF36-v2), pain (Visual analogue scale), fatigue (Modified Fatigue Index Scale) and functional assessments (Brookes and Vignos). RESULTS: FSHD and BMD reported worse sleep than CTRL on the PSQI. FSHD scored worse than CTRL on the Insomnia Severity Index (P<0.05). 25–63% and 50–81% of adults with MD reported poor sleep quality using the Insomnia Severity Index and PSQI, respectively. Accelerometery identified no difference in sleep quality between groups. Associations were identified between sleep measures (PSQI global and insomnia severity) with mental or physical QoL in LGMD, BMD and FSHD. Multiple regression identified associations between sleep impairment and fatigue severity (all MDs), body composition (BMD & LGMD), upper and lower limb function (LGMD, FSHD) and age (FSHD). CONCLUSIONS: 25–81% of men with MD, depending on classification, experience sleep impairment, using self-report sleep measures. Whilst BMD and FSHD showed worse sleep outcomes than CTRL, no group difference was observed between LGMD and CTRL, however all groups showed associations with sleep impairment and higher levels of fatigue. These findings, and associations with measures of health and wellbeing, highlight an area for further research which could impact QoL in adults with MD. Public Library of Science 2022-09-22 /pmc/articles/PMC9499246/ /pubmed/36137167 http://dx.doi.org/10.1371/journal.pone.0274970 Text en © 2022 Morse et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Morse, Christopher I. Onambele-Pearson, Gladys Edwards, Bryn Wong, Sze Choong Jacques, Matthew F. Objective and subjective measures of sleep in men with Muscular Dystrophy |
title | Objective and subjective measures of sleep in men with Muscular Dystrophy |
title_full | Objective and subjective measures of sleep in men with Muscular Dystrophy |
title_fullStr | Objective and subjective measures of sleep in men with Muscular Dystrophy |
title_full_unstemmed | Objective and subjective measures of sleep in men with Muscular Dystrophy |
title_short | Objective and subjective measures of sleep in men with Muscular Dystrophy |
title_sort | objective and subjective measures of sleep in men with muscular dystrophy |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499246/ https://www.ncbi.nlm.nih.gov/pubmed/36137167 http://dx.doi.org/10.1371/journal.pone.0274970 |
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