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Regional variation in brain tissue texture in patients with tonic-clonic seizures
Patients with epilepsy, who later succumb to sudden unexpected death, show altered brain tissue volumes in selected regions. It is unclear whether the alterations in brain tissue volume represent changes in neurons or glial properties, since volumetric procedures have limited sensitivity to assess t...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499268/ https://www.ncbi.nlm.nih.gov/pubmed/36137154 http://dx.doi.org/10.1371/journal.pone.0274514 |
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author | Ogren, Jennifer A. Allen, Luke A. Roy, Bhaswati Diehl, Beate Stern, John M. Eliashiv, Dawn S. Lhatoo, Samden D. Harper, Ronald M. Kumar, Rajesh |
author_facet | Ogren, Jennifer A. Allen, Luke A. Roy, Bhaswati Diehl, Beate Stern, John M. Eliashiv, Dawn S. Lhatoo, Samden D. Harper, Ronald M. Kumar, Rajesh |
author_sort | Ogren, Jennifer A. |
collection | PubMed |
description | Patients with epilepsy, who later succumb to sudden unexpected death, show altered brain tissue volumes in selected regions. It is unclear whether the alterations in brain tissue volume represent changes in neurons or glial properties, since volumetric procedures have limited sensitivity to assess the source of volume changes (e.g., neuronal loss or glial cell swelling). We assessed a measure, entropy, which can determine tissue homogeneity by evaluating tissue randomness, and thus, shows tissue integrity; the measure is easily calculated from T1-weighted images. T1-weighted images were collected with a 3.0-Tesla MRI from 53 patients with tonic-clonic (TC) seizures and 53 healthy controls; images were bias-corrected, entropy maps calculated, normalized to a common space, smoothed, and compared between groups (TC patients and controls using ANCOVA; covariates, age and sex; SPM12, family-wise error correction for multiple comparisons, p<0.01). Decreased entropy, indicative of increased tissue homogeneity, appeared in major autonomic (ventromedial prefrontal cortex, hippocampus, dorsal and ventral medulla, deep cerebellar nuclei), motor (sensory and motor cortex), or both motor and autonomic regulatory sites (basal-ganglia, ventral-basal cerebellum), and external surfaces of the pons. The anterior and posterior thalamus and midbrain also showed entropy declines. Only a few isolated regions showed increased entropy. Among the spared autonomic regions was the anterior cingulate and anterior insula; the posterior insula and cingulate were, however, affected. The entropy alterations overlapped areas of tissue changes found earlier with volumetric measures, but were more extensive, and indicate widespread injury to tissue within critical autonomic and breathing regulatory areas, as well as prominent damage to more-rostral sites that exert influences on both breathing and cardiovascular regulation. The entropy measures provide easily-collected supplementary information using only T1-weighted images, showing aspects of tissue integrity other than volume change that are important for assessing function. |
format | Online Article Text |
id | pubmed-9499268 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-94992682022-09-23 Regional variation in brain tissue texture in patients with tonic-clonic seizures Ogren, Jennifer A. Allen, Luke A. Roy, Bhaswati Diehl, Beate Stern, John M. Eliashiv, Dawn S. Lhatoo, Samden D. Harper, Ronald M. Kumar, Rajesh PLoS One Research Article Patients with epilepsy, who later succumb to sudden unexpected death, show altered brain tissue volumes in selected regions. It is unclear whether the alterations in brain tissue volume represent changes in neurons or glial properties, since volumetric procedures have limited sensitivity to assess the source of volume changes (e.g., neuronal loss or glial cell swelling). We assessed a measure, entropy, which can determine tissue homogeneity by evaluating tissue randomness, and thus, shows tissue integrity; the measure is easily calculated from T1-weighted images. T1-weighted images were collected with a 3.0-Tesla MRI from 53 patients with tonic-clonic (TC) seizures and 53 healthy controls; images were bias-corrected, entropy maps calculated, normalized to a common space, smoothed, and compared between groups (TC patients and controls using ANCOVA; covariates, age and sex; SPM12, family-wise error correction for multiple comparisons, p<0.01). Decreased entropy, indicative of increased tissue homogeneity, appeared in major autonomic (ventromedial prefrontal cortex, hippocampus, dorsal and ventral medulla, deep cerebellar nuclei), motor (sensory and motor cortex), or both motor and autonomic regulatory sites (basal-ganglia, ventral-basal cerebellum), and external surfaces of the pons. The anterior and posterior thalamus and midbrain also showed entropy declines. Only a few isolated regions showed increased entropy. Among the spared autonomic regions was the anterior cingulate and anterior insula; the posterior insula and cingulate were, however, affected. The entropy alterations overlapped areas of tissue changes found earlier with volumetric measures, but were more extensive, and indicate widespread injury to tissue within critical autonomic and breathing regulatory areas, as well as prominent damage to more-rostral sites that exert influences on both breathing and cardiovascular regulation. The entropy measures provide easily-collected supplementary information using only T1-weighted images, showing aspects of tissue integrity other than volume change that are important for assessing function. Public Library of Science 2022-09-22 /pmc/articles/PMC9499268/ /pubmed/36137154 http://dx.doi.org/10.1371/journal.pone.0274514 Text en © 2022 Ogren et al https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the terms of the Creative Commons Attribution License (https://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Ogren, Jennifer A. Allen, Luke A. Roy, Bhaswati Diehl, Beate Stern, John M. Eliashiv, Dawn S. Lhatoo, Samden D. Harper, Ronald M. Kumar, Rajesh Regional variation in brain tissue texture in patients with tonic-clonic seizures |
title | Regional variation in brain tissue texture in patients with tonic-clonic seizures |
title_full | Regional variation in brain tissue texture in patients with tonic-clonic seizures |
title_fullStr | Regional variation in brain tissue texture in patients with tonic-clonic seizures |
title_full_unstemmed | Regional variation in brain tissue texture in patients with tonic-clonic seizures |
title_short | Regional variation in brain tissue texture in patients with tonic-clonic seizures |
title_sort | regional variation in brain tissue texture in patients with tonic-clonic seizures |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499268/ https://www.ncbi.nlm.nih.gov/pubmed/36137154 http://dx.doi.org/10.1371/journal.pone.0274514 |
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