Cargando…

Multiple Perspectives Reveal the Role of DNA Damage Repair Genes in the Molecular Classification and Prognosis of Pancreatic Adenocarcinoma

Pancreatic adenocarcinoma (PAAD) is a highly heterogeneous and immunosuppressive cancer. This study investigated the diversity of DNA damage repair (DDR) and immune microenvironment in PAAD by transcriptomic and genomic analysis. Patients with PAAD were divided into two DDR-based subtypes with disti...

Descripción completa

Detalles Bibliográficos
Autores principales:	Li, Yujie, Zhang, Ke, Peng, Linjia, Chen, Lianyu, Gao, Huifeng, Chen, Hao
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499455/ https://www.ncbi.nlm.nih.gov/pubmed/36142142 http://dx.doi.org/10.3390/ijms231810231

Ejemplares similares

Real-World Evidence of Traditional Chinese Medicine (TCM) Treatment on Cancer: A Literature-Based Review
por: Peng, Linjia, et al.
Publicado: (2022)

The Pre-Ablation Circulating Tumor-Associated Inflammatory Index Predicts the Prognosis of Patients with Liver Metastasis from Pancreatic Cancer
por: Li, Yujie, et al.
Publicado: (2022)

DNA Damage Repair Deficiency in Pancreatic Ductal Adenocarcinoma: Preclinical Models and Clinical Perspectives
por: Stoof, Jojanneke, et al.
Publicado: (2021)

A novel nomogram and risk classification system based on inflammatory and immune indicators for predicting prognosis of pancreatic cancer patients with liver metastases
por: Peng, Linjia, et al.
Publicado: (2023)

Overexpression of pyruvate dehydrogenase phosphatase 1 promotes the progression of pancreatic adenocarcinoma by regulating energy-related AMPK/mTOR signaling
por: Li, Ye, et al.
Publicado: (2020)

Determination of a DNA repair-related gene signature with potential implications for prognosis and therapeutic response in pancreatic adenocarcinoma
por: Lai, Jinzhi, et al.
Publicado: (2022)

Comprehensive analysis identifies DNA damage repair-related gene HCLS1 associated with good prognosis in lung adenocarcinoma
por: Liu, Tingjun, et al.
Publicado: (2023)

DNA damage repair as a target in pancreatic cancer: state-of-the-art and future perspectives
por: Perkhofer, Lukas, et al.
Publicado: (2021)

Germline Variants in DNA Damage Repair Genes: An Emerging Role in the Era of Precision Medicine in Pancreatic Adenocarcinoma
por: Shoucair, Sami, et al.
Publicado: (2021)

ITGB5 promotes innate radiation resistance in pancreatic adenocarcinoma by promoting DNA damage repair and the MEK/ERK signaling pathway
por: Wen, Xin, et al.
Publicado: (2022)

DNA damage and repair in the hematopoietic system: DNA damage and repair in the hematopoietic system
por: Li, Niu, et al.
Publicado: (2022)

Functional inhibition of lactate dehydrogenase suppresses pancreatic adenocarcinoma progression
por: Cheng, Chien‐shan, et al.
Publicado: (2021)

Understanding DNA Damage Response and DNA Repair in Multiple Myeloma
por: Petrilla, Cole, et al.
Publicado: (2023)

DNA damage repair mutations in pancreatic cancer– prognostic or predictive?
por: Hu, Ya-Fei, et al.
Publicado: (2023)

The Role of Alternative Splicing Factors, DDB2-Related Ageing and DNA Damage Repair in the Progression and Prognosis of Stomach Adenocarcinoma Patients
por: Wang, Xinshu, et al.
Publicado: (2022)

The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma
por: Shui, Lin, et al.
Publicado: (2021)

DNA Damage and Repair in Atherosclerosis: Current Insights and Future Perspectives
por: Cervelli, Tiziana, et al.
Publicado: (2012)

The DNA methylation profile of non-coding RNAs improves prognosis prediction for pancreatic adenocarcinoma
por: Zhang, Jie, et al.
Publicado: (2019)

Identification of potential crucial genes associated with the pathogenesis and prognosis of pancreatic adenocarcinoma
por: Shi, Lan-Er, et al.
Publicado: (2020)

Resting T cells are hypersensitive to DNA damage due to defective DNA repair pathway
por: Hu, Qian, et al.
Publicado: (2018)

Correction to: The germline/somatic DNA damage repair gene mutations modulate the therapeutic response in Chinese patients with advanced pancreatic ductal adenocarcinoma
por: Shui, Lin, et al.
Publicado: (2021)

Research progress on the role and mechanism of DNA damage repair in germ cell development
por: Wang, Yan, et al.
Publicado: (2023)

Prognostic Predicting Role of Contrast-Enhanced Computed Tomography for Locally Advanced Pancreatic Adenocarcinoma
por: Cheng, Chien-shan, et al.
Publicado: (2019)

DNA Damage Repair Status Predicts Opposite Clinical Prognosis Immunotherapy and Non-Immunotherapy in Hepatocellular Carcinoma
por: Chen, Yunfei, et al.
Publicado: (2021)

Combination of Tumor Mutational Burden and DNA Damage Repair Gene Mutations with Stromal/Immune Scores Improved Prognosis Stratification in Patients with Lung Adenocarcinoma
por: Wu, Dongping, et al.
Publicado: (2022)

Retrospective review of outcomes in patients with DNA-damage repair related pancreatic cancer
por: Macklin-Mantia, Sarah K., et al.
Publicado: (2020)

GDPLichi: a DNA Damage Repair-Related Gene Classifier for Predicting Lung Adenocarcinoma Immune Checkpoint Inhibitors Response
por: Leng, Yang, et al.
Publicado: (2021)

Immunogenic cell death-associated biomarkers classification predicts prognosis and immunotherapy efficacy in pancreatic ductal adenocarcinoma
por: Peng, Wenguang, et al.
Publicado: (2023)

DNA Repair Genes Are Associated with Subtype Classification, Prognosis, and Immune Infiltration in Uveal Melanoma
por: Wang, Tao, et al.
Publicado: (2022)

Cell-Free DNA Sequencing Reveals Gene Variants in DNA Damage Repair Genes Associated with Prognosis of Prostate Cancer Patients
por: Lieb, Verena, et al.
Publicado: (2022)

DNA Damage, Mutagenesis, and DNA Repair
por: Basu, Ashis, et al.
Publicado: (2010)

The role of DNA damage and repair in decitabine-mediated apoptosis in multiple myeloma
por: Maes, Ken, et al.
Publicado: (2014)

Differentiation of chronic mass-forming pancreatitis from pancreatic ductal adenocarcinoma using contrast-enhanced computed tomography
por: Ren, Shuai, et al.
Publicado: (2019)

A Novel DNA Damage Repair-Related Gene Signature for Predicting Glioma Prognosis
por: Zhan, Jiaoyang, et al.
Publicado: (2021)

A CDC7 inhibitor sensitizes DNA-damaging chemotherapies by suppressing homologous recombination repair to delay DNA damage recovery
por: Iwai, Kenichi, et al.
Publicado: (2021)

Classification and Prognosis Analysis of Pancreatic Cancer Based on DNA Methylation Profile and Clinical Information
por: Li, Xin, et al.
Publicado: (2022)

Pancreatic Ductal Adenocarcinoma: Relating Biomechanics and Prognosis
por: MacCurtain, Benjamin M., et al.
Publicado: (2021)

Repair of radiation damage to DNA
por: Willers, H, et al.
Publicado: (2004)

DNA Damage, Repair, and Diseases
por: Wiesmüller, Lisa, et al.
Publicado: (2002)

Aptamers for DNA Damage and Repair
por: McKeague, Maureen
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_52hakfgrp7sdi9meh96s506oa7