Homologous recombination–deficient mutation cluster in tumor suppressor RAD51C identified by comprehensive analysis of cancer variants

Mutations in homologous recombination (HR) genes, including BRCA1, BRCA2, and the RAD51 paralog RAD51C, predispose to tumorigenesis and sensitize cancers to DNA-damaging agents and poly(ADP ribose) polymerase inhibitors. However, ∼800 missense variants of unknown significance have been identified fo...

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Detalles Bibliográficos
Autores principales: Prakash, Rohit, Rawal, Yashpal, Sullivan, Meghan R., Grundy, McKenzie K., Bret, Hélène, Mihalevic, Michael J., Rein, Hayley L., Baird, Jared M., Darrah, Kristie, Zhang, Fang, Wang, Raymond, Traina, Tiffany A., Radke, Marc R., Kaufmann, Scott H., Swisher, Elizabeth M., Guérois, Raphaël, Modesti, Mauro, Sung, Patrick, Jasin, Maria, Bernstein, Kara A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499524/
https://www.ncbi.nlm.nih.gov/pubmed/36099300
http://dx.doi.org/10.1073/pnas.2202727119

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