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Recurrent emergence of Klebsiella pneumoniae carbapenem resistance mediated by an inhibitory ompK36 mRNA secondary structure
Outer membrane porins in Gram-negative bacteria facilitate antibiotic influx. In Klebsiella pneumoniae, modifications in the porin OmpK36 are implicated in increasing resistance to carbapenems. An analysis of large K. pneumoniae genome collections, encompassing major healthcare-associated clones, re...
Autores principales: | Wong, Joshua L. C., David, Sophia, Sanchez-Garrido, Julia, Woo, Jia Z., Low, Wen Wen, Morecchiato, Fabio, Giani, Tommaso, Rossolini, Gian Maria, Beis, Konstantinos, Brett, Stephen J., Clements, Abigail, Aanensen, David M., Rouskin, Silvi, Frankel, Gad |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
National Academy of Sciences
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499542/ https://www.ncbi.nlm.nih.gov/pubmed/36095213 http://dx.doi.org/10.1073/pnas.2203593119 |
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