Deletion of a previously uncharacterized lipoprotein lirL confers resistance to an inhibitor of type II signal peptidase in Acinetobacter baumannii

Acinetobacter baumannii is a clinically important, predominantly health care–associated gram-negative bacterium with high rates of emerging resistance worldwide. Given the urgent need for novel antibacterial therapies against A. baumannii, we focused on inhibiting lipoprotein biosynthesis, a pathway...

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Detalles Bibliográficos
Autores principales: Huang, Ke-Jung, Pantua, Homer, Diao, Jingyu, Skippington, Elizabeth, Volny, Michael, Sandoval, Wendy, Tiku, Varnesh, Peng, Yutian, Sagolla, Meredith, Yan, Donghong, Kang, Jing, Katakam, Anand Kumar, Michaelian, Nairie, Reichelt, Mike, Tan, Man-Wah, Austin, Cary D., Xu, Min, Hanan, Emily, Kapadia, Sharookh B.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499571/
https://www.ncbi.nlm.nih.gov/pubmed/36099298
http://dx.doi.org/10.1073/pnas.2123117119

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