Nanobodies and chemical cross-links advance the structural and functional analysis of PI3Kα

Nanobodies and chemical cross-linking were used to gain information on the identity and positions of flexible domains of PI3Kα. The application of chemical cross-linking mass spectrometry (CXMS) facilitated the identification of the p85 domains BH, cSH2, and SH3 as well as their docking positions on...

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Detalles Bibliográficos
Autores principales: Hart, Jonathan R., Liu, Xiao, Pan, Chen, Liang, Anyi, Ueno, Lynn, Xu, Yingna, Quezada, Alexandra, Zou, Xinyu, Yang, Su, Zhou, Qingtong, Schoonooghe, Steve, Hassanzadeh-Ghassabeh, Gholamreza, Xia, Tian, Shui, Wenqing, Yang, Dehua, Vogt, Peter K., Wang, Ming-Wei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: National Academy of Sciences 2022
Materias:
Biological Sciences
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499577/
https://www.ncbi.nlm.nih.gov/pubmed/36095215
http://dx.doi.org/10.1073/pnas.2210769119

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