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The Role of DNA Methylation in Stroke Recovery
Epigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltr...
Autores principales: | , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499691/ https://www.ncbi.nlm.nih.gov/pubmed/36142283 http://dx.doi.org/10.3390/ijms231810373 |
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author | Choi, Dong-Hee Choi, In-Ae Lee, Jongmin |
author_facet | Choi, Dong-Hee Choi, In-Ae Lee, Jongmin |
author_sort | Choi, Dong-Hee |
collection | PubMed |
description | Epigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltransferase (DNMT), which promotes methylation, DNA demethylase, which removes methyl groups, and methyl-cytosine–phosphate–guanine-binding domain (MBD) protein, which binds methylated DNA and inhibits gene expression. Investigating the effects of modulating DNMT, TET, and MBD protein expression on neuronal cell death and neurorepair in ischemic stroke and elucidating the underlying mechanisms can facilitate the formulation of therapeutic strategies for neuroprotection and promotion of neuronal recovery after stroke. In this review, we summarize the role of DNA methylation in neuroprotection and neuronal recovery after stroke according to the current knowledge regarding the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. This review of the literature regarding the role of DNA methylation in neuroprotection and functional recovery after stroke may contribute to the development and application of novel therapeutic strategies for stroke. |
format | Online Article Text |
id | pubmed-9499691 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-94996912022-09-23 The Role of DNA Methylation in Stroke Recovery Choi, Dong-Hee Choi, In-Ae Lee, Jongmin Int J Mol Sci Review Epigenetic alterations affect the onset of ischemic stroke, brain injury after stroke, and mechanisms of poststroke recovery. In particular, DNA methylation can be dynamically altered by maintaining normal brain function or inducing abnormal brain damage. DNA methylation is regulated by DNA methyltransferase (DNMT), which promotes methylation, DNA demethylase, which removes methyl groups, and methyl-cytosine–phosphate–guanine-binding domain (MBD) protein, which binds methylated DNA and inhibits gene expression. Investigating the effects of modulating DNMT, TET, and MBD protein expression on neuronal cell death and neurorepair in ischemic stroke and elucidating the underlying mechanisms can facilitate the formulation of therapeutic strategies for neuroprotection and promotion of neuronal recovery after stroke. In this review, we summarize the role of DNA methylation in neuroprotection and neuronal recovery after stroke according to the current knowledge regarding the effects of DNA methylation on excitotoxicity, oxidative stress, apoptosis, neuroinflammation, and recovery after ischemic stroke. This review of the literature regarding the role of DNA methylation in neuroprotection and functional recovery after stroke may contribute to the development and application of novel therapeutic strategies for stroke. MDPI 2022-09-08 /pmc/articles/PMC9499691/ /pubmed/36142283 http://dx.doi.org/10.3390/ijms231810373 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Choi, Dong-Hee Choi, In-Ae Lee, Jongmin The Role of DNA Methylation in Stroke Recovery |
title | The Role of DNA Methylation in Stroke Recovery |
title_full | The Role of DNA Methylation in Stroke Recovery |
title_fullStr | The Role of DNA Methylation in Stroke Recovery |
title_full_unstemmed | The Role of DNA Methylation in Stroke Recovery |
title_short | The Role of DNA Methylation in Stroke Recovery |
title_sort | role of dna methylation in stroke recovery |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499691/ https://www.ncbi.nlm.nih.gov/pubmed/36142283 http://dx.doi.org/10.3390/ijms231810373 |
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