Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis

We presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complet...

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Autores principales: Cheung, Florence M. F., So, Timothy Y. C., Sung, Tony H. T., Lam, Ying-Lee
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Case Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499769/
https://www.ncbi.nlm.nih.gov/pubmed/36158567
http://dx.doi.org/10.1155/2022/1992541
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author Cheung, Florence M. F.
So, Timothy Y. C.
Sung, Tony H. T.
Lam, Ying-Lee
author_facet Cheung, Florence M. F.
So, Timothy Y. C.
Sung, Tony H. T.
Lam, Ying-Lee
author_sort Cheung, Florence M. F.
collection PubMed
description We presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complete curettage specimen with relevant immunohistochemistry and molecular tests made the final diagnosis of DTSGCT possible. The biomolecular mechanism for the masquerading phenomenon was explained by CSF1 overexpression in the neoplastic cells attracting migration and proliferation of CSF1R-positive Langerhans cells.
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spelling pubmed-94997692022-09-23 Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis Cheung, Florence M. F. So, Timothy Y. C. Sung, Tony H. T. Lam, Ying-Lee Case Rep Med Case Report We presented a case of diffuse-type tenosynovial giant cell tumour (DTSGCT) of foot masquerading as Langerhans cell histiocytosis. Preliminary diagnosis by needle biopsy was difficult due to the major involvement of bones and the overshadowing effect of the accompanying Langerhans cells. The complete curettage specimen with relevant immunohistochemistry and molecular tests made the final diagnosis of DTSGCT possible. The biomolecular mechanism for the masquerading phenomenon was explained by CSF1 overexpression in the neoplastic cells attracting migration and proliferation of CSF1R-positive Langerhans cells. Hindawi 2022-09-15 /pmc/articles/PMC9499769/ /pubmed/36158567 http://dx.doi.org/10.1155/2022/1992541 Text en Copyright © 2022 Florence M. F. Cheung et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Case Report
Cheung, Florence M. F.
So, Timothy Y. C.
Sung, Tony H. T.
Lam, Ying-Lee
Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
title Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
title_full Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
title_fullStr Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
title_full_unstemmed Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
title_short Diffuse-Type Tenosynovial Giant Cell Tumour Involving Bone Masquerading as Langerhans Cell Histiocytosis
title_sort diffuse-type tenosynovial giant cell tumour involving bone masquerading as langerhans cell histiocytosis
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499769/
https://www.ncbi.nlm.nih.gov/pubmed/36158567
http://dx.doi.org/10.1155/2022/1992541
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