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Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation

Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α...

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Autores principales: Bak, Seon Gyeong, Lim, Hyung-Jin, Won, Yeong-Seon, Lee, Soyoung, Cheong, Sun Hee, Lee, Seong Jin, Bae, Eun Young, Lee, Seung Woong, Lee, Seung Jae, Rho, Mun-Chual
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499794/
https://www.ncbi.nlm.nih.gov/pubmed/36158872
http://dx.doi.org/10.1155/2022/2475699
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author Bak, Seon Gyeong
Lim, Hyung-Jin
Won, Yeong-Seon
Lee, Soyoung
Cheong, Sun Hee
Lee, Seong Jin
Bae, Eun Young
Lee, Seung Woong
Lee, Seung Jae
Rho, Mun-Chual
author_facet Bak, Seon Gyeong
Lim, Hyung-Jin
Won, Yeong-Seon
Lee, Soyoung
Cheong, Sun Hee
Lee, Seong Jin
Bae, Eun Young
Lee, Seung Woong
Lee, Seung Jae
Rho, Mun-Chual
author_sort Bak, Seon Gyeong
collection PubMed
description Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases.
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spelling pubmed-94997942022-09-23 Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation Bak, Seon Gyeong Lim, Hyung-Jin Won, Yeong-Seon Lee, Soyoung Cheong, Sun Hee Lee, Seong Jin Bae, Eun Young Lee, Seung Woong Lee, Seung Jae Rho, Mun-Chual Biomed Res Int Research Article Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases. Hindawi 2022-09-15 /pmc/articles/PMC9499794/ /pubmed/36158872 http://dx.doi.org/10.1155/2022/2475699 Text en Copyright © 2022 Seon Gyeong Bak et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Research Article
Bak, Seon Gyeong
Lim, Hyung-Jin
Won, Yeong-Seon
Lee, Soyoung
Cheong, Sun Hee
Lee, Seong Jin
Bae, Eun Young
Lee, Seung Woong
Lee, Seung Jae
Rho, Mun-Chual
Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
title Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
title_full Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
title_fullStr Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
title_full_unstemmed Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
title_short Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
title_sort regulatory effects of lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammation
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499794/
https://www.ncbi.nlm.nih.gov/pubmed/36158872
http://dx.doi.org/10.1155/2022/2475699
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