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Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation
Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α...
Autores principales: | , , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Hindawi
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499794/ https://www.ncbi.nlm.nih.gov/pubmed/36158872 http://dx.doi.org/10.1155/2022/2475699 |
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author | Bak, Seon Gyeong Lim, Hyung-Jin Won, Yeong-Seon Lee, Soyoung Cheong, Sun Hee Lee, Seong Jin Bae, Eun Young Lee, Seung Woong Lee, Seung Jae Rho, Mun-Chual |
author_facet | Bak, Seon Gyeong Lim, Hyung-Jin Won, Yeong-Seon Lee, Soyoung Cheong, Sun Hee Lee, Seong Jin Bae, Eun Young Lee, Seung Woong Lee, Seung Jae Rho, Mun-Chual |
author_sort | Bak, Seon Gyeong |
collection | PubMed |
description | Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases. |
format | Online Article Text |
id | pubmed-9499794 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Hindawi |
record_format | MEDLINE/PubMed |
spelling | pubmed-94997942022-09-23 Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation Bak, Seon Gyeong Lim, Hyung-Jin Won, Yeong-Seon Lee, Soyoung Cheong, Sun Hee Lee, Seong Jin Bae, Eun Young Lee, Seung Woong Lee, Seung Jae Rho, Mun-Chual Biomed Res Int Research Article Lycium barbarum and scopoletin are widely used in oriental Eastern medicine and are often consumed as teas. In this study, proinflammatory cytokines expressed in human keratinocytes (HaCaT) were induced by skin diseases caused by 2,4-dinitrochlorobenzene (DNCB) and tumor necrosis factor alpha (TNF-α)/interferon gamma (IFN-γ). The inhibitory activity of L. barbarum EtOH extract (LBE) and scopoletin on proinflammatory cytokines and chemokines was investigated. In the DNCB-induced animal model, oral administration of LBE inhibited skin lesions and proinflammatory cytokines and chemokines and showed inhibitory effects in vitro. Additionally, as a result of examining the efficacy of scopoletin isolated from L. barbarum, scopoletin in HaCaT cells showed inhibitory effects on proinflammatory cytokines and chemokines. It shows promise in the treatment of chronic skin diseases. Hindawi 2022-09-15 /pmc/articles/PMC9499794/ /pubmed/36158872 http://dx.doi.org/10.1155/2022/2475699 Text en Copyright © 2022 Seon Gyeong Bak et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. |
spellingShingle | Research Article Bak, Seon Gyeong Lim, Hyung-Jin Won, Yeong-Seon Lee, Soyoung Cheong, Sun Hee Lee, Seong Jin Bae, Eun Young Lee, Seung Woong Lee, Seung Jae Rho, Mun-Chual Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation |
title | Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation |
title_full | Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation |
title_fullStr | Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation |
title_full_unstemmed | Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation |
title_short | Regulatory Effects of Lycium barbarum Extract and Isolated Scopoletin on Atopic Dermatitis-Like Skin Inflammation |
title_sort | regulatory effects of lycium barbarum extract and isolated scopoletin on atopic dermatitis-like skin inflammation |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499794/ https://www.ncbi.nlm.nih.gov/pubmed/36158872 http://dx.doi.org/10.1155/2022/2475699 |
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