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A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics

What benefit might emerge from connecting clinical neuroscience with microbiology and exercise science? What about the influence of the muscle-gut-brain (MGB) axis on mental health? The gut microbiota colonizes the intestinal tract and plays a pivotal role in digestion, production of vitamins and im...

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Autores principales: Cammisuli, Davide Maria, Fusi, Jonathan, Scarfò, Giorgia, Daniele, Simona, Castelnuovo, Gianluca, Franzoni, Ferdinando
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Hindawi 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499796/
https://www.ncbi.nlm.nih.gov/pubmed/36160716
http://dx.doi.org/10.1155/2022/8806009
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author Cammisuli, Davide Maria
Fusi, Jonathan
Scarfò, Giorgia
Daniele, Simona
Castelnuovo, Gianluca
Franzoni, Ferdinando
author_facet Cammisuli, Davide Maria
Fusi, Jonathan
Scarfò, Giorgia
Daniele, Simona
Castelnuovo, Gianluca
Franzoni, Ferdinando
author_sort Cammisuli, Davide Maria
collection PubMed
description What benefit might emerge from connecting clinical neuroscience with microbiology and exercise science? What about the influence of the muscle-gut-brain (MGB) axis on mental health? The gut microbiota colonizes the intestinal tract and plays a pivotal role in digestion, production of vitamins and immune system development, but it is also able to exert a particular effect on psychological well-being and appears to play a critical role in regulating several muscle metabolic pathways. Endogenous and exogenous factors may cause dysbiosis, with relevant consequences on the composition and function of the gut microbiota that may also modulate muscle responses to exercise. The capacity of specific psychobiotics in ameliorating mental health as complementary strategies has been recently suggested as a novel treatment for some neuropsychiatric diseases. Moreover, physical exercise can modify qualitative and quantitative composition of the gut microbiota and alleviate certain psychopathological symptoms. In this minireview, we documented evidence about the impact of the MGB axis on mental health, which currently appears to be a possible target in the context of a multidimensional intervention mainly including pharmacological and psychotherapeutic treatments, especially for depressive mood.
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spelling pubmed-94997962022-09-23 A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics Cammisuli, Davide Maria Fusi, Jonathan Scarfò, Giorgia Daniele, Simona Castelnuovo, Gianluca Franzoni, Ferdinando Oxid Med Cell Longev Review Article What benefit might emerge from connecting clinical neuroscience with microbiology and exercise science? What about the influence of the muscle-gut-brain (MGB) axis on mental health? The gut microbiota colonizes the intestinal tract and plays a pivotal role in digestion, production of vitamins and immune system development, but it is also able to exert a particular effect on psychological well-being and appears to play a critical role in regulating several muscle metabolic pathways. Endogenous and exogenous factors may cause dysbiosis, with relevant consequences on the composition and function of the gut microbiota that may also modulate muscle responses to exercise. The capacity of specific psychobiotics in ameliorating mental health as complementary strategies has been recently suggested as a novel treatment for some neuropsychiatric diseases. Moreover, physical exercise can modify qualitative and quantitative composition of the gut microbiota and alleviate certain psychopathological symptoms. In this minireview, we documented evidence about the impact of the MGB axis on mental health, which currently appears to be a possible target in the context of a multidimensional intervention mainly including pharmacological and psychotherapeutic treatments, especially for depressive mood. Hindawi 2022-09-15 /pmc/articles/PMC9499796/ /pubmed/36160716 http://dx.doi.org/10.1155/2022/8806009 Text en Copyright © 2022 Davide Maria Cammisuli et al. https://creativecommons.org/licenses/by/4.0/This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Review Article
Cammisuli, Davide Maria
Fusi, Jonathan
Scarfò, Giorgia
Daniele, Simona
Castelnuovo, Gianluca
Franzoni, Ferdinando
A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
title A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
title_full A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
title_fullStr A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
title_full_unstemmed A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
title_short A Minireview Exploring the Interplay of the Muscle-Gut-Brain (MGB) Axis to Improve Knowledge on Mental Disorders: Implications for Clinical Neuroscience Research and Therapeutics
title_sort minireview exploring the interplay of the muscle-gut-brain (mgb) axis to improve knowledge on mental disorders: implications for clinical neuroscience research and therapeutics
topic Review Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499796/
https://www.ncbi.nlm.nih.gov/pubmed/36160716
http://dx.doi.org/10.1155/2022/8806009
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