Transplantation of human neural progenitor cells secreting GDNF into the spinal cord of patients with ALS: a phase 1/2a trial

Amyotrophic lateral sclerosis (ALS) involves progressive motor neuron loss, leading to paralysis and death typically within 3–5 years of diagnosis. Dysfunctional astrocytes may contribute to disease and glial cell line-derived neurotrophic factor (GDNF) can be protective. Here we show that human neu...

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Detalles Bibliográficos
Autores principales: Baloh, Robert H., Johnson, J. Patrick, Avalos, Pablo, Allred, Peggy, Svendsen, Soshana, Gowing, Genevieve, Roxas, Kristina, Wu, Amanda, Donahue, Becky, Osborne, Sheryl, Lawless, George, Shelley, Brandon, Wheeler, Koral, Prina, Carolyn, Fine, Dana, Kendra-Romito, Tami, Stokes, Haniah, Manoukian, Vicki, Muthukumaran, Abirami, Garcia, Leslie, Bañuelos, Maria G., Godoy, Marlesa, Bresee, Catherine, Yu, Hong, Drazin, Doniel, Ross, Lindsey, Naruse, Robert, Babu, Harish, Macklin, Eric A., Vo, Ashley, Elsayegh, Ashraf, Tourtellotte, Warren, Maya, Marcel, Burford, Matthew, Diaz, Frank, Patil, Chirag G., Lewis, Richard A., Svendsen, Clive N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499868/
https://www.ncbi.nlm.nih.gov/pubmed/36064599
http://dx.doi.org/10.1038/s41591-022-01956-3

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