Neutralization titer biomarker for antibody-mediated prevention of HIV-1 acquisition

The Antibody Mediated Prevention trials showed that the broadly neutralizing antibody (bnAb) VRC01 prevented acquisition of human immunodeficiency virus-1 (HIV-1) sensitive to VRC01. Using AMP trial data, here we show that the predicted serum neutralization 80% inhibitory dilution titer (PT(80)) bio...

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Detalles Bibliográficos
Autores principales: Gilbert, Peter B., Huang, Yunda, deCamp, Allan C., Karuna, Shelly, Zhang, Yuanyuan, Magaret, Craig A., Giorgi, Elena E., Korber, Bette, Edlefsen, Paul T., Rossenkhan, Raabya, Juraska, Michal, Rudnicki, Erika, Kochar, Nidhi, Huang, Ying, Carpp, Lindsay N., Barouch, Dan H., Mkhize, Nonhlanhla N., Hermanus, Tandile, Kgagudi, Prudence, Bekker, Valerie, Kaldine, Haajira, Mapengo, Rutendo E., Eaton, Amanda, Domin, Elize, West, Carley, Feng, Wenhong, Tang, Haili, Seaton, Kelly E., Heptinstall, Jack, Brackett, Caroline, Chiong, Kelvin, Tomaras, Georgia D., Andrew, Philip, Mayer, Bryan T., Reeves, Daniel B., Sobieszczyk, Magdalena E., Garrett, Nigel, Sanchez, Jorge, Gay, Cynthia, Makhema, Joseph, Williamson, Carolyn, Mullins, James I., Hural, John, Cohen, Myron S., Corey, Lawrence, Montefiori, David C., Morris, Lynn
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499869/
https://www.ncbi.nlm.nih.gov/pubmed/35995954
http://dx.doi.org/10.1038/s41591-022-01953-6

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