Ectopic JAK–STAT activation enables the transition to a stem-like and multilineage state conferring AR-targeted therapy resistance

Emerging evidence indicates that various cancers can gain resistance to targeted therapies by acquiring lineage plasticity. Although various genomic and transcriptomic aberrations correlate with lineage plasticity, the molecular mechanisms enabling the acquisition of lineage plasticity have not been...

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Detalles Bibliográficos
Autores principales: Deng, Su, Wang, Choushi, Wang, Yunguan, Xu, Yaru, Li, Xiaoling, Johnson, Nickolas A., Mukherji, Atreyi, Lo, U-Ging, Xu, Lingfan, Gonzalez, Julisa, Metang, Lauren A., Ye, Jianfeng, Tirado, Carla Rodriguez, Rodarte, Kathia, Zhou, Yinglu, Xie, Zhiqun, Arana, Carlos, Annamalai, Valli, Liu, Xihui, Vander Griend, Donald J., Strand, Douglas, Hsieh, Jer-Tsong, Li, Bo, Raj, Ganesh, Wang, Tao, Mu, Ping
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group US 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499870/
https://www.ncbi.nlm.nih.gov/pubmed/36065066
http://dx.doi.org/10.1038/s43018-022-00431-9

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