BCGΔBCG1419c increased memory CD8(+) T cell-associated immunogenicity and mitigated pulmonary inflammation compared with BCG in a model of chronic tuberculosis

Previously, we reported that a hygromycin resistant version of the BCGΔBCG1419c vaccine candidate reduced tuberculosis (TB) disease in BALB/c, C57BL/6, and B6D2F1 mice infected with Mycobacterium tuberculosis (Mtb) H37Rv. Here, the second-generation version of BCGΔBCG1419c (based on BCG Pasteur ATCC...

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Detalles Bibliográficos
Autores principales: Kwon, Kee Woong, Aceves-Sánchez, Michel de Jesús, Segura-Cerda, Cristian Alfredo, Choi, Eunsol, Bielefeldt-Ohmann, Helle, Shin, Sung Jae, Flores-Valdez, Mario Alberto
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499934/
https://www.ncbi.nlm.nih.gov/pubmed/36138053
http://dx.doi.org/10.1038/s41598-022-20017-w

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