Intratumoral heterogeneity of c-KIT mutations in a feline splenic mast cell tumor and their functional effects on cell proliferation

A cat was presented with mast cell tumors (MCTs) of the skin and spleen. During the initial diagnosis, the exon 8 mutation of c-KIT was detected in the masses from skin and spleen by a commercial laboratory test. Consequently, treatment with toceranib was started. After complete remission, because o...

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Detalles Bibliográficos
Autores principales: Hasegawa, Yuki, Shosu, Kazuha, Tsuji, kanako, Shimoyama, Yumiko, Miyama, Takako Shimokawa, Baba, Kenji, Okuda, Masaru, Itamoto, Kazuhito, Igase, Masaya, Mizuno, Takuya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499958/
https://www.ncbi.nlm.nih.gov/pubmed/36138037
http://dx.doi.org/10.1038/s41598-022-19089-5

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