A next-generation iPSC-derived forebrain organoid model of tauopathy with tau fibrils by AAV-mediated gene transfer

It is known that the human cellular models of Alzheimer’s disease (AD) and tauopathy can only recapitulate the very early stage of the disease. To overcome these limitations, we developed a technology to make forebrain organoids (FBOs) from feeder-free induced pluripotent stem cells (iPSC)s by regul...

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Detalles Bibliográficos
Autores principales: Shimada, Hiroko, Sato, Yuta, Sasaki, Takashi, Shimozawa, Aki, Imaizumi, Kent, Shindo, Tomoko, Miyao, Sachiyo, Kiyama, Kosuke, Kondo, Takahiro, Shibata, Shinsuke, Ishii, Seiji, Kuromitsu, Junro, Aoyagi, Hirofumi, Ito, Daisuke, Okano, Hideyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499998/
https://www.ncbi.nlm.nih.gov/pubmed/36160042
http://dx.doi.org/10.1016/j.crmeth.2022.100289

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