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Robust genome editing via modRNA-based Cas9 or base editor in human pluripotent stem cells
CRISPR systems have revolutionized biomedical research because they offer an unprecedented opportunity for genome editing. However, a bottleneck of applying CRISPR systems in human pluripotent stem cells (hPSCs) is how to deliver CRISPR effectors easily and efficiently. Here, we developed modified m...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Elsevier
2022
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9499999/ https://www.ncbi.nlm.nih.gov/pubmed/36160051 http://dx.doi.org/10.1016/j.crmeth.2022.100290 |