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Deep-learning analysis of micropattern-based organoids enables high-throughput drug screening of Huntington’s disease models
Organoids are carrying the promise of modeling complex disease phenotypes and serving as a powerful basis for unbiased drug screens, potentially offering a more efficient drug-discovery route. However, unsolved technical bottlenecks of reproducibility and scalability have prevented the use of curren...
Autores principales: | Metzger, Jakob J., Pereda, Carlota, Adhikari, Arjun, Haremaki, Tomomi, Galgoczi, Szilvia, Siggia, Eric D., Brivanlou, Ali H., Etoc, Fred |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Elsevier
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500000/ https://www.ncbi.nlm.nih.gov/pubmed/36160045 http://dx.doi.org/10.1016/j.crmeth.2022.100297 |
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