Protein condensation diseases: therapeutic opportunities

Condensed states of proteins, including liquid-like membraneless organelles and solid-like aggregates, contribute in fundamental ways to the organisation and function of the cell. Perturbations of these states can lead to a variety of diseases through mechanisms that we are now beginning to understa...

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Autores principales: Vendruscolo, Michele, Fuxreiter, Monika
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Perspective
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500012/
https://www.ncbi.nlm.nih.gov/pubmed/36138006
http://dx.doi.org/10.1038/s41467-022-32940-7
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author Vendruscolo, Michele
Fuxreiter, Monika
author_facet Vendruscolo, Michele
Fuxreiter, Monika
author_sort Vendruscolo, Michele
collection PubMed
description Condensed states of proteins, including liquid-like membraneless organelles and solid-like aggregates, contribute in fundamental ways to the organisation and function of the cell. Perturbations of these states can lead to a variety of diseases through mechanisms that we are now beginning to understand. We define protein condensation diseases as conditions caused by the disruption of the normal behaviour of the condensed states of proteins. We analyze the problem of the identification of targets for pharmacological interventions for these diseases and explore opportunities for the regulation of the formation and organisation of aberrant condensed states of proteins.
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spelling pubmed-95000122022-09-24 Protein condensation diseases: therapeutic opportunities Vendruscolo, Michele Fuxreiter, Monika Nat Commun Perspective Condensed states of proteins, including liquid-like membraneless organelles and solid-like aggregates, contribute in fundamental ways to the organisation and function of the cell. Perturbations of these states can lead to a variety of diseases through mechanisms that we are now beginning to understand. We define protein condensation diseases as conditions caused by the disruption of the normal behaviour of the condensed states of proteins. We analyze the problem of the identification of targets for pharmacological interventions for these diseases and explore opportunities for the regulation of the formation and organisation of aberrant condensed states of proteins. Nature Publishing Group UK 2022-09-22 /pmc/articles/PMC9500012/ /pubmed/36138006 http://dx.doi.org/10.1038/s41467-022-32940-7 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Perspective
Vendruscolo, Michele
Fuxreiter, Monika
Protein condensation diseases: therapeutic opportunities
title Protein condensation diseases: therapeutic opportunities
title_full Protein condensation diseases: therapeutic opportunities
title_fullStr Protein condensation diseases: therapeutic opportunities
title_full_unstemmed Protein condensation diseases: therapeutic opportunities
title_short Protein condensation diseases: therapeutic opportunities
title_sort protein condensation diseases: therapeutic opportunities
topic Perspective
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500012/
https://www.ncbi.nlm.nih.gov/pubmed/36138006
http://dx.doi.org/10.1038/s41467-022-32940-7
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