Chromatin organizer SATB1 controls the cell identity of CD4(+) CD8(+) double-positive thymocytes by regulating the activity of super-enhancers

CD4(+) and CD8(+) double-positive (DP) thymocytes play a crucial role in T cell development in the thymus. DP cells rearrange the T cell receptor gene Tcra to generate T cell receptors with TCRβ. DP cells differentiate into CD4 or CD8 single-positive (SP) thymocytes, regulatory T cells, or invariant...

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Detalles Bibliográficos
Autores principales: Feng, Delong, Chen, Yanhong, Dai, Ranran, Bian, Shasha, Xue, Wei, Zhu, Yongchang, Li, Zhaoqiang, Yang, Yiting, Zhang, Yan, Zhang, Jiarui, Bai, Jie, Qin, Litao, Kohwi, Yoshinori, Shi, Weili, Kohwi-Shigematsu, Terumi, Ma, Jing, Liao, Shixiu, Hao, Bingtao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500044/
https://www.ncbi.nlm.nih.gov/pubmed/36138028
http://dx.doi.org/10.1038/s41467-022-33333-6

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