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Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants

Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of...

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Autores principales: Toledano-Serrabona, Jorge, Bosch, Begoña M., Díez-Tercero, Leire, Gil, F. Javier, Camps-Font, Octavi, Valmaseda-Castellón, Eduard, Gay-Escoda, Cosme, Sánchez-Garcés, Mª Ángeles
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500064/
https://www.ncbi.nlm.nih.gov/pubmed/36138061
http://dx.doi.org/10.1038/s41598-022-20100-2
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author Toledano-Serrabona, Jorge
Bosch, Begoña M.
Díez-Tercero, Leire
Gil, F. Javier
Camps-Font, Octavi
Valmaseda-Castellón, Eduard
Gay-Escoda, Cosme
Sánchez-Garcés, Mª Ángeles
author_facet Toledano-Serrabona, Jorge
Bosch, Begoña M.
Díez-Tercero, Leire
Gil, F. Javier
Camps-Font, Octavi
Valmaseda-Castellón, Eduard
Gay-Escoda, Cosme
Sánchez-Garcés, Mª Ángeles
author_sort Toledano-Serrabona, Jorge
collection PubMed
description Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-α and a decreased expression of TGF-β and CD206. Regarding cytokine release, there was an increase in IL-1β, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers.
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spelling pubmed-95000642022-09-24 Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants Toledano-Serrabona, Jorge Bosch, Begoña M. Díez-Tercero, Leire Gil, F. Javier Camps-Font, Octavi Valmaseda-Castellón, Eduard Gay-Escoda, Cosme Sánchez-Garcés, Mª Ángeles Sci Rep Article Implantoplasty is a mechanical decontamination technique that consists of removing the threads and polishing and smoothing the dental implant surface. During implantoplasty there is a large release of titanium metal particles that might provoke a proinflammatory response and reduce the viability of osteogenic cells. We analyze the inflammatory and osteogenic response induced by Ti6Al4V particles released during implantoplasty and by as-received commercially pure Ti particles. Macrophages stimulated with metal particles obtained by implantoplasty and with as-received Ti particles showed an increased proinflammatory expression of TNF-α and a decreased expression of TGF-β and CD206. Regarding cytokine release, there was an increase in IL-1β, while IL-10 decreased. The osteogenic response of Ti6Al4V extracts showed a significant decrease in Runx2 and OC expression compared to the controls and commercially pure Ti extracts. There were no relevant changes in ALP activity. Thus, implantoplasty releases metal particles that seems to induce a pro-inflammatory response and reduce the expression of osteogenic markers. Nature Publishing Group UK 2022-09-22 /pmc/articles/PMC9500064/ /pubmed/36138061 http://dx.doi.org/10.1038/s41598-022-20100-2 Text en © The Author(s) 2022 https://creativecommons.org/licenses/by/4.0/Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/ (https://creativecommons.org/licenses/by/4.0/) .
spellingShingle Article
Toledano-Serrabona, Jorge
Bosch, Begoña M.
Díez-Tercero, Leire
Gil, F. Javier
Camps-Font, Octavi
Valmaseda-Castellón, Eduard
Gay-Escoda, Cosme
Sánchez-Garcés, Mª Ángeles
Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
title Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
title_full Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
title_fullStr Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
title_full_unstemmed Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
title_short Evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
title_sort evaluation of the inflammatory and osteogenic response induced by titanium particles released during implantoplasty of dental implants
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500064/
https://www.ncbi.nlm.nih.gov/pubmed/36138061
http://dx.doi.org/10.1038/s41598-022-20100-2
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