Topical application of an irreversible small molecule inhibitor of lysyl oxidases ameliorates skin scarring and fibrosis

Scarring is a lifelong consequence of skin injury, with scar stiffness and poor appearance presenting physical and psychological barriers to a return to normal life. Lysyl oxidases are a family of enzymes that play a critical role in scar formation and maintenance. Lysyl oxidases stabilize the main...

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Detalles Bibliográficos
Autores principales: Chaudhari, Nutan, Findlay, Alison D., Stevenson, Andrew W., Clemons, Tristan D., Yao, Yimin, Joshi, Amar, Sayyar, Sepidar, Wallace, Gordon, Rea, Suzanne, Toshniwal, Priyanka, Deng, Zhenjun, Melton, Philip E., Hortin, Nicole, Iyer, K. Swaminathan, Jarolimek, Wolfgang, Wood, Fiona M., Fear, Mark W.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500072/
https://www.ncbi.nlm.nih.gov/pubmed/36138009
http://dx.doi.org/10.1038/s41467-022-33148-5

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