Roles of CD4+ T cells as mediators of antitumor immunity

It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that...

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Autores principales: Kravtsov, Dmitriy S., Erbe, Amy K., Sondel, Paul M., Rakhmilevich, Alexander L.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500154/
https://www.ncbi.nlm.nih.gov/pubmed/36159781
http://dx.doi.org/10.3389/fimmu.2022.972021
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author Kravtsov, Dmitriy S.
Erbe, Amy K.
Sondel, Paul M.
Rakhmilevich, Alexander L.
author_facet Kravtsov, Dmitriy S.
Erbe, Amy K.
Sondel, Paul M.
Rakhmilevich, Alexander L.
author_sort Kravtsov, Dmitriy S.
collection PubMed
description It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that CD4+ T cells can also mediate antitumor immunity either directly by killing tumor cells or indirectly by activating innate immune cells or by reducing tumor angiogenesis. In this review, we discuss the growing evidence of this underappreciated role of CD4+ T cells as mediators of antitumor immunity.
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spelling pubmed-95001542022-09-24 Roles of CD4+ T cells as mediators of antitumor immunity Kravtsov, Dmitriy S. Erbe, Amy K. Sondel, Paul M. Rakhmilevich, Alexander L. Front Immunol Immunology It has been well established that CD8+ T cells serve as effector cells of the adaptive immune response against tumors, whereas CD4+ T cells either help or suppress the generation of CD8+ cytotoxic T cells. However, in several experimental models as well as in cancer patients, it has been shown that CD4+ T cells can also mediate antitumor immunity either directly by killing tumor cells or indirectly by activating innate immune cells or by reducing tumor angiogenesis. In this review, we discuss the growing evidence of this underappreciated role of CD4+ T cells as mediators of antitumor immunity. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500154/ /pubmed/36159781 http://dx.doi.org/10.3389/fimmu.2022.972021 Text en Copyright © 2022 Kravtsov, Erbe, Sondel and Rakhmilevich https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Immunology
Kravtsov, Dmitriy S.
Erbe, Amy K.
Sondel, Paul M.
Rakhmilevich, Alexander L.
Roles of CD4+ T cells as mediators of antitumor immunity
title Roles of CD4+ T cells as mediators of antitumor immunity
title_full Roles of CD4+ T cells as mediators of antitumor immunity
title_fullStr Roles of CD4+ T cells as mediators of antitumor immunity
title_full_unstemmed Roles of CD4+ T cells as mediators of antitumor immunity
title_short Roles of CD4+ T cells as mediators of antitumor immunity
title_sort roles of cd4+ t cells as mediators of antitumor immunity
topic Immunology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500154/
https://www.ncbi.nlm.nih.gov/pubmed/36159781
http://dx.doi.org/10.3389/fimmu.2022.972021
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