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Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma

Glioma is the most common tumour of the central nervous system, with a poor prognosis and an increasing trend of incidence in recent years; it is also beginning to affect younger age groups more. Added to this, cuproptosis is a new form of cell death. Indeed, when a certain amount of copper accumula...

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Autores principales: Ouyang, Zhen, Zhang, Hanyi, Lin, Wenrui, Su, Juan, Wang, Xianggui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500213/
https://www.ncbi.nlm.nih.gov/pubmed/36158220
http://dx.doi.org/10.3389/fcell.2022.982439
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author Ouyang, Zhen
Zhang, Hanyi
Lin, Wenrui
Su, Juan
Wang, Xianggui
author_facet Ouyang, Zhen
Zhang, Hanyi
Lin, Wenrui
Su, Juan
Wang, Xianggui
author_sort Ouyang, Zhen
collection PubMed
description Glioma is the most common tumour of the central nervous system, with a poor prognosis and an increasing trend of incidence in recent years; it is also beginning to affect younger age groups more. Added to this, cuproptosis is a new form of cell death. Indeed, when a certain amount of copper accumulates in a cell, it affects specific mitochondrial metabolic enzymes in that cell and leads to cell death–a phenomenon known as cuproptosis. In this study, we applied bioinformatics analysis, and, according to the results of the study analysis and Gene Ontology (GO), as well as the Kyoto Encyclopedia of Genes and Genomes KyotoEncyclopediaofGenesandGenomes, the glutaminase (GLS) genes affect the prognosis and tumour mutation of glioma patients through cuproptosis. Interestingly, however, GLS is not involved in the immune escape of glioma. Glutaminase genes are a class of glucose metabolism-related genes that are involved in the tricarboxylic acid cycle of cells. At the same time, the expression of the glutaminase gene was positively correlated with the degree of immune cell infiltration and the expression of various immune cell markers, and thus affected the prognosis of glioma patients. Therefore, we believe that the cuproptosis-related glutaminase gene can be an important factor in determining the prognosis of glioma patients.
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spelling pubmed-95002132022-09-24 Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma Ouyang, Zhen Zhang, Hanyi Lin, Wenrui Su, Juan Wang, Xianggui Front Cell Dev Biol Cell and Developmental Biology Glioma is the most common tumour of the central nervous system, with a poor prognosis and an increasing trend of incidence in recent years; it is also beginning to affect younger age groups more. Added to this, cuproptosis is a new form of cell death. Indeed, when a certain amount of copper accumulates in a cell, it affects specific mitochondrial metabolic enzymes in that cell and leads to cell death–a phenomenon known as cuproptosis. In this study, we applied bioinformatics analysis, and, according to the results of the study analysis and Gene Ontology (GO), as well as the Kyoto Encyclopedia of Genes and Genomes KyotoEncyclopediaofGenesandGenomes, the glutaminase (GLS) genes affect the prognosis and tumour mutation of glioma patients through cuproptosis. Interestingly, however, GLS is not involved in the immune escape of glioma. Glutaminase genes are a class of glucose metabolism-related genes that are involved in the tricarboxylic acid cycle of cells. At the same time, the expression of the glutaminase gene was positively correlated with the degree of immune cell infiltration and the expression of various immune cell markers, and thus affected the prognosis of glioma patients. Therefore, we believe that the cuproptosis-related glutaminase gene can be an important factor in determining the prognosis of glioma patients. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500213/ /pubmed/36158220 http://dx.doi.org/10.3389/fcell.2022.982439 Text en Copyright © 2022 Ouyang, Zhang, Lin, Su and Wang. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Ouyang, Zhen
Zhang, Hanyi
Lin, Wenrui
Su, Juan
Wang, Xianggui
Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
title Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
title_full Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
title_fullStr Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
title_full_unstemmed Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
title_short Bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
title_sort bioinformatic profiling identifies the glutaminase to be a potential novel cuproptosis-related biomarker for glioma
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500213/
https://www.ncbi.nlm.nih.gov/pubmed/36158220
http://dx.doi.org/10.3389/fcell.2022.982439
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