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Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer
BACKGROUND: Breast cancer is the most common malignant tumor among women worldwide, and breast cancer stem cells (BCSCs) are believed to be the source of tumorigenesis. New findings suggest that small nucleolar RNAs (snoRNAs) play a significant role in tumor development. METHODS: The Cancer Genome A...
Autores principales: | , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500313/ https://www.ncbi.nlm.nih.gov/pubmed/36158687 http://dx.doi.org/10.3389/fonc.2022.930024 |
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author | Song, Jian Zheng, Ang Li, Shan Zhang, Wenrong Zhang, Meilin Li, Xingzhe Jin, Feng Ji, Ziyao |
author_facet | Song, Jian Zheng, Ang Li, Shan Zhang, Wenrong Zhang, Meilin Li, Xingzhe Jin, Feng Ji, Ziyao |
author_sort | Song, Jian |
collection | PubMed |
description | BACKGROUND: Breast cancer is the most common malignant tumor among women worldwide, and breast cancer stem cells (BCSCs) are believed to be the source of tumorigenesis. New findings suggest that small nucleolar RNAs (snoRNAs) play a significant role in tumor development. METHODS: The Cancer Genome Atlas (TCGA) and Kaplan–Meier survival analysis were used to demonstrate expression and survival of SNORA38 signature. In situ hybridization (ISH) and immunohistochemical (IHC) were conducted to analyze the correlation between SNORA38 and stemness biomarker in 77 BC samples. Gene Set Enrichment Analysis (GSEA) was performed to investigate the mechanisms related to SNORA38 expression in BC. Real-time qPCR was employed to evaluate the expression of SNORA38 in breast cancer cell lines. RESULTS: In the public database and patients’ biopsies, SNORA38 was significantly up-regulated in breast cancer. Furthermore, the expression of SNORA38 was significantly correlated with tumor size, lymph node metastasis, and TNM stage, among which tumor size was an independent factor for SNORA38 expression. Higher SNORA38 expression was associated with shorter overall survival (OS). Meanwhile, SNORA38 was positively associated with the stem cell marker OCT-4, which suggested that SNORA38 might be related to breast cancer stemness. CONCLUSIONS: SNORA38 is an important carcinogenic snoRNA in breast cancer and might be a prognostic biomarker for breast cancer. |
format | Online Article Text |
id | pubmed-9500313 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95003132022-09-24 Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer Song, Jian Zheng, Ang Li, Shan Zhang, Wenrong Zhang, Meilin Li, Xingzhe Jin, Feng Ji, Ziyao Front Oncol Oncology BACKGROUND: Breast cancer is the most common malignant tumor among women worldwide, and breast cancer stem cells (BCSCs) are believed to be the source of tumorigenesis. New findings suggest that small nucleolar RNAs (snoRNAs) play a significant role in tumor development. METHODS: The Cancer Genome Atlas (TCGA) and Kaplan–Meier survival analysis were used to demonstrate expression and survival of SNORA38 signature. In situ hybridization (ISH) and immunohistochemical (IHC) were conducted to analyze the correlation between SNORA38 and stemness biomarker in 77 BC samples. Gene Set Enrichment Analysis (GSEA) was performed to investigate the mechanisms related to SNORA38 expression in BC. Real-time qPCR was employed to evaluate the expression of SNORA38 in breast cancer cell lines. RESULTS: In the public database and patients’ biopsies, SNORA38 was significantly up-regulated in breast cancer. Furthermore, the expression of SNORA38 was significantly correlated with tumor size, lymph node metastasis, and TNM stage, among which tumor size was an independent factor for SNORA38 expression. Higher SNORA38 expression was associated with shorter overall survival (OS). Meanwhile, SNORA38 was positively associated with the stem cell marker OCT-4, which suggested that SNORA38 might be related to breast cancer stemness. CONCLUSIONS: SNORA38 is an important carcinogenic snoRNA in breast cancer and might be a prognostic biomarker for breast cancer. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500313/ /pubmed/36158687 http://dx.doi.org/10.3389/fonc.2022.930024 Text en Copyright © 2022 Song, Zheng, Li, Zhang, Zhang, Li, Jin and Ji https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Oncology Song, Jian Zheng, Ang Li, Shan Zhang, Wenrong Zhang, Meilin Li, Xingzhe Jin, Feng Ji, Ziyao Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer |
title | Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer |
title_full | Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer |
title_fullStr | Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer |
title_full_unstemmed | Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer |
title_short | Clinical significance and prognostic value of small nucleolar RNA SNORA38 in breast cancer |
title_sort | clinical significance and prognostic value of small nucleolar rna snora38 in breast cancer |
topic | Oncology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500313/ https://www.ncbi.nlm.nih.gov/pubmed/36158687 http://dx.doi.org/10.3389/fonc.2022.930024 |
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