Cargando…

Control of mitochondrial dynamics and apoptotic pathways by peroxisomes

Peroxisomes are organelles containing different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. Peroxisome biogenesis is controlled by a family of proteins called peroxins, which are required for peroxisomal membrane...

Descripción completa

Detalles Bibliográficos
Autores principales: Jiang, Chenxing, Okazaki, Tomohiko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500405/
https://www.ncbi.nlm.nih.gov/pubmed/36158224
http://dx.doi.org/10.3389/fcell.2022.938177
_version_ 1784795214537293824
author Jiang, Chenxing
Okazaki, Tomohiko
author_facet Jiang, Chenxing
Okazaki, Tomohiko
author_sort Jiang, Chenxing
collection PubMed
description Peroxisomes are organelles containing different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. Peroxisome biogenesis is controlled by a family of proteins called peroxins, which are required for peroxisomal membrane formation, matrix protein transport, and division. Mutations of peroxins cause metabolic disorders called peroxisomal biogenesis disorders, among which Zellweger syndrome (ZS) is the most severe. Although patients with ZS exhibit severe pathology in multiple organs such as the liver, kidney, brain, muscle, and bone, the pathogenesis remains largely unknown. Recent findings indicate that peroxisomes regulate intrinsic apoptotic pathways and upstream fission-fusion processes, disruption of which causes multiple organ dysfunctions reminiscent of ZS. In this review, we summarize recent findings about peroxisome-mediated regulation of mitochondrial morphology and its possible relationship with the pathogenesis of ZS.
format Online
Article
Text
id pubmed-9500405
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95004052022-09-24 Control of mitochondrial dynamics and apoptotic pathways by peroxisomes Jiang, Chenxing Okazaki, Tomohiko Front Cell Dev Biol Cell and Developmental Biology Peroxisomes are organelles containing different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. Peroxisome biogenesis is controlled by a family of proteins called peroxins, which are required for peroxisomal membrane formation, matrix protein transport, and division. Mutations of peroxins cause metabolic disorders called peroxisomal biogenesis disorders, among which Zellweger syndrome (ZS) is the most severe. Although patients with ZS exhibit severe pathology in multiple organs such as the liver, kidney, brain, muscle, and bone, the pathogenesis remains largely unknown. Recent findings indicate that peroxisomes regulate intrinsic apoptotic pathways and upstream fission-fusion processes, disruption of which causes multiple organ dysfunctions reminiscent of ZS. In this review, we summarize recent findings about peroxisome-mediated regulation of mitochondrial morphology and its possible relationship with the pathogenesis of ZS. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500405/ /pubmed/36158224 http://dx.doi.org/10.3389/fcell.2022.938177 Text en Copyright © 2022 Jiang and Okazaki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Cell and Developmental Biology
Jiang, Chenxing
Okazaki, Tomohiko
Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
title Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
title_full Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
title_fullStr Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
title_full_unstemmed Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
title_short Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
title_sort control of mitochondrial dynamics and apoptotic pathways by peroxisomes
topic Cell and Developmental Biology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500405/
https://www.ncbi.nlm.nih.gov/pubmed/36158224
http://dx.doi.org/10.3389/fcell.2022.938177
work_keys_str_mv AT jiangchenxing controlofmitochondrialdynamicsandapoptoticpathwaysbyperoxisomes
AT okazakitomohiko controlofmitochondrialdynamicsandapoptoticpathwaysbyperoxisomes