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Control of mitochondrial dynamics and apoptotic pathways by peroxisomes
Peroxisomes are organelles containing different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. Peroxisome biogenesis is controlled by a family of proteins called peroxins, which are required for peroxisomal membrane...
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Formato: | Online Artículo Texto |
Lenguaje: | English |
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Frontiers Media S.A.
2022
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Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500405/ https://www.ncbi.nlm.nih.gov/pubmed/36158224 http://dx.doi.org/10.3389/fcell.2022.938177 |
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author | Jiang, Chenxing Okazaki, Tomohiko |
author_facet | Jiang, Chenxing Okazaki, Tomohiko |
author_sort | Jiang, Chenxing |
collection | PubMed |
description | Peroxisomes are organelles containing different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. Peroxisome biogenesis is controlled by a family of proteins called peroxins, which are required for peroxisomal membrane formation, matrix protein transport, and division. Mutations of peroxins cause metabolic disorders called peroxisomal biogenesis disorders, among which Zellweger syndrome (ZS) is the most severe. Although patients with ZS exhibit severe pathology in multiple organs such as the liver, kidney, brain, muscle, and bone, the pathogenesis remains largely unknown. Recent findings indicate that peroxisomes regulate intrinsic apoptotic pathways and upstream fission-fusion processes, disruption of which causes multiple organ dysfunctions reminiscent of ZS. In this review, we summarize recent findings about peroxisome-mediated regulation of mitochondrial morphology and its possible relationship with the pathogenesis of ZS. |
format | Online Article Text |
id | pubmed-9500405 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95004052022-09-24 Control of mitochondrial dynamics and apoptotic pathways by peroxisomes Jiang, Chenxing Okazaki, Tomohiko Front Cell Dev Biol Cell and Developmental Biology Peroxisomes are organelles containing different enzymes that catalyze various metabolic pathways such as β-oxidation of very long-chain fatty acids and synthesis of plasmalogens. Peroxisome biogenesis is controlled by a family of proteins called peroxins, which are required for peroxisomal membrane formation, matrix protein transport, and division. Mutations of peroxins cause metabolic disorders called peroxisomal biogenesis disorders, among which Zellweger syndrome (ZS) is the most severe. Although patients with ZS exhibit severe pathology in multiple organs such as the liver, kidney, brain, muscle, and bone, the pathogenesis remains largely unknown. Recent findings indicate that peroxisomes regulate intrinsic apoptotic pathways and upstream fission-fusion processes, disruption of which causes multiple organ dysfunctions reminiscent of ZS. In this review, we summarize recent findings about peroxisome-mediated regulation of mitochondrial morphology and its possible relationship with the pathogenesis of ZS. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500405/ /pubmed/36158224 http://dx.doi.org/10.3389/fcell.2022.938177 Text en Copyright © 2022 Jiang and Okazaki. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Cell and Developmental Biology Jiang, Chenxing Okazaki, Tomohiko Control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
title | Control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
title_full | Control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
title_fullStr | Control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
title_full_unstemmed | Control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
title_short | Control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
title_sort | control of mitochondrial dynamics and apoptotic pathways by peroxisomes |
topic | Cell and Developmental Biology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500405/ https://www.ncbi.nlm.nih.gov/pubmed/36158224 http://dx.doi.org/10.3389/fcell.2022.938177 |
work_keys_str_mv | AT jiangchenxing controlofmitochondrialdynamicsandapoptoticpathwaysbyperoxisomes AT okazakitomohiko controlofmitochondrialdynamicsandapoptoticpathwaysbyperoxisomes |