Cargando…

Can learnings from the COVID-19 pandemic improve trial conduct post-pandemic? A case study of strategies used by the DISC trial

BACKGROUND: RCTs often face issues such as slow recruitment, poor intervention adherence and high attrition, however the 2020/2021 COVID-19 pandemic intensified these challenges. Strategies employed by the DISC trial to overcome pandemic-related barriers to recruitment, treatment delivery and retent...

Descripción completa

Detalles Bibliográficos
Autores principales:	Knowlson, Catherine, Tharmanathan, Puvan, Arundel, Catherine, James, Sophie, Flett, Lydia, Gascoyne, Samantha, Welch, Charlie, Warwick, David, Dias, Joseph
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	SAGE Publications 2022
Materias:	Original Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500425/ http://dx.doi.org/10.1177/26320843221128296

Ejemplares similares

Dupuytren’s interventions surgery versus collagenase (DISC) trial: study protocol for a pragmatic, two-arm parallel-group, non-inferiority randomised controlled trial
por: Dias, Joseph, et al.
Publicado: (2021)

Cost-effectiveness of hydroxychloroquine versus placebo for hand osteoarthritis: economic evaluation of the HERO trial
por: Ronaldson, Sarah J, et al.
Publicado: (2021)

Recruiting ahead of target: What worked in the REEACT trial?
por: Tharmanathan, Puvan, et al.
Publicado: (2011)

The use of interim data and Data Monitoring Committee recommendations in randomized controlled trial reports: frequency, implications and potential sources of bias
por: Tharmanathan, Puvan, et al.
Publicado: (2008)

Ongoing validation of health-related quality of life instruments
por: Cocks, Kim, et al.
Publicado: (2015)

Reverse shoulder arthroplasty versus hemiarthroplasty versus non-surgical treatment for older adults with acute 3- or 4-part fractures of the proximal humerus: study protocol for a randomised controlled trial (PROFHER-2: PROximal Fracture of Humerus Evaluation by Randomisation – Trial Number 2)
por: Rangan, Amar, et al.
Publicado: (2023)

Analysis of longitudinal oncology quality of life (QoL) data - are we getting it right?
por: Cocks, Kim, et al.
Publicado: (2013)

Effects of rapid recruitment and dissemination on Covid-19 mortality: the RECOVERY trial
por: Knowlson, Catherine, et al.
Publicado: (2020)

Examination of early treatment effects and related biases during the conduct of two UK-wide pragmatic orthopaedic surgical trials: ProFHER and UK FROST
por: Knowlson, Catherine N., et al.
Publicado: (2023)

Bah humbug! Association between sending Christmas cards to trial participants and trial retention: randomised study within a trial conducted simultaneously across eight host trials
por: Coleman, Elizabeth, et al.
Publicado: (2021)

Learning from OCTET – exploring the acceptability of clinical trials management methods
por: Arundel, Catherine, et al.
Publicado: (2018)

Recruitment and retention interventions in surgical and wound care trials: A systematic review
por: Arundel, Catherine, et al.
Publicado: (2023)

Computerised cognitive behaviour therapy (cCBT) as treatment for depression in primary care (REEACT trial): large scale pragmatic randomised controlled trial
por: Gilbody, Simon, et al.
Publicado: (2015)

Conducting dermatology clinical trials during the COVID-19 pandemic
por: Sheriff, Tabrez, et al.
Publicado: (2021)

A nested randomised controlled trial of a leaflet, containing information on research, to increase the recruitment rate of reform (reducing falls with orthoses and a multifaceted podiatry) trial participants
por: Arundel, Catherine, et al.
Publicado: (2013)

Challenges and opportunities for sponsors in conducting clinical trials during a pandemic
por: Davis, Sanish, et al.
Publicado: (2020)

Effectively Conducting Oncology Clinical Trials During the COVID-19 Pandemic
por: Yeboa, Debra Nana, et al.
Publicado: (2021)

Conducting clinical trials during the COVID-19 pandemic—a collaborative trial network response
por: Robison, Laura, et al.
Publicado: (2021)

The effectiveness of a contingent financial incentive to improve trial follow up; a randomised study within a trial (SWAT)
por: Arundel, Catherine, et al.
Publicado: (2020)

Pain reduction with oral methotrexate in knee osteoarthritis, a pragmatic phase iii trial of treatment effectiveness (PROMOTE): study protocol for a randomized controlled trial
por: Kingsbury, Sarah R, et al.
Publicado: (2015)

Additional consensus recommendations for conducting complex innovative trials of oncology agents: a post-pandemic perspective
por: Blagden, Sarah P., et al.
Publicado: (2022)

The COVID-19 pandemic and a reflection on the conduct of clinical trials in times of war
por: Pacheco, Rafael Leite, et al.
Publicado: (2021)

Impact of the COVID-19 pandemic on the conduct of clinical trials: a quantitative analysis
por: Margas, Wojciech, et al.
Publicado: (2022)

Hydroxychloroquine effectiveness in reducing symptoms of hand osteoarthritis (HERO): study protocol for a randomized controlled trial
por: Kingsbury, Sarah R, et al.
Publicado: (2013)

Compression therapies for the treatment of venous leg ulcers: study protocol for a process evaluation in a randomised controlled trial, VenUS 6
por: Kletter, Maartje, et al.
Publicado: (2023)

How the COVID-19 pandemic is changing clinical trial conduct and driving innovation in bioanalysis
por: Anderson, Melanie
Publicado: (2021)

Using pens as an incentive for trial recruitment of older adults: An embedded randomised controlled trial
por: Whiteside, Katie, et al.
Publicado: (2019)

Study within a trial (SWAT) protocol. Investigating the effect of personalised versus non-personalised study invitations on recruitment: An embedded randomised controlled recruitment trial
por: Woodford, Joanne, et al.
Publicado: (2020)

Smoking Cessation Intervention for Severe Mental Ill Health Trial (SCIMITAR+): study protocol for a randomised controlled trial
por: Peckham, Emily, et al.
Publicado: (2017)

How to Conduct a Clinical Trial During a Pandemic—An Interview with Dr. David Boulware
Publicado: (2020)

Challenges and opportunities for conducting a vaccine trial during the COVID-19 pandemic in the United Kingdom
por: Török, M Estée, et al.
Publicado: (2021)

Conducting a supportive oncology clinical trial during the COVID-19 pandemic: challenges and strategies
por: Deng, Jie, et al.
Publicado: (2022)

“Direct and indirect impacts of the COVID-19 pandemic on operational conduct of pediatric vaccine clinical trials”
por: McArthur, Monica Anne, et al.
Publicado: (2023)

A single experience in the conduction of clinical trial during COronaVIrusDisease-2019 pandemic
por: Ballatore, Zelmira, et al.
Publicado: (2023)

Participation in community-based lung cancer screening: the Yorkshire Lung Screening Trial
por: Crosbie, Philip A.J., et al.
Publicado: (2022)

Accelerating vaccine trial conduct in a pandemic with a hot spot‐based inclusion strategy using trial and epidemic simulation
por: van der Plas, Johan L., et al.
Publicado: (2021)

P10 Biomarker Driven Antifungal Stewardship in Acute Leukaemia (BioDriveAFS)—a multicentre randomized controlled trial to assess clinical and cost effectiveness
por: Taynton, Thomas, et al.
Publicado: (2022)

Rapid Adaptation of a Surgical Research Unit to Conduct Clinical Trials During the COVID-19 Pandemic
por: Emamaullee, Juliet, et al.
Publicado: (2020)

Lessons Learned From Conducting Internet-Based Randomized Clinical Trials During a Global Pandemic
por: Pullen, Matthew F, et al.
Publicado: (2020)

Conducting a pediatric randomized clinical trial during a pandemic: A shift to virtual procedures
por: Roberts, James R., et al.
Publicado: (2022)

Cannot write session to /tmp/vufind_sessions/sess_85dogkcvmrmlv93tktrab5biog