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Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, on...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500435/ https://www.ncbi.nlm.nih.gov/pubmed/36158959 http://dx.doi.org/10.3389/fneur.2022.989340 |
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author | Hernandez-Martin, Estefania Arguelles, Enrique Liker, Mark Robison, Aaron Sanger, Terence D. |
author_facet | Hernandez-Martin, Estefania Arguelles, Enrique Liker, Mark Robison, Aaron Sanger, Terence D. |
author_sort | Hernandez-Martin, Estefania |
collection | PubMed |
description | The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, one was undergoing testing for treatment of Tourette Syndrome and had neither dystonia nor abnormal movements during testing. Movement-related signals were evaluated by determining the magnitude of task-related frequency components. Brain signals were recorded in globus pallidus internus (GPi), the ventral oralis anterior/posterior (VoaVop) and the ventral intermediate (Vim) nuclei of the thalamus. In comparison to the subject without dystonia, both children with dystonia showed increased task-related activity in GPi and Vim. This finding is consistent with a role of both basal ganglia and cerebellar outputs in the pathogenesis of dystonia. Our results further suggest that frequency analysis of brain recordings during cyclic movements may be a useful tool for analysis of the presence of movement-related signals in various brain regions. |
format | Online Article Text |
id | pubmed-9500435 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95004352022-09-24 Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia Hernandez-Martin, Estefania Arguelles, Enrique Liker, Mark Robison, Aaron Sanger, Terence D. Front Neurol Neurology The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, one was undergoing testing for treatment of Tourette Syndrome and had neither dystonia nor abnormal movements during testing. Movement-related signals were evaluated by determining the magnitude of task-related frequency components. Brain signals were recorded in globus pallidus internus (GPi), the ventral oralis anterior/posterior (VoaVop) and the ventral intermediate (Vim) nuclei of the thalamus. In comparison to the subject without dystonia, both children with dystonia showed increased task-related activity in GPi and Vim. This finding is consistent with a role of both basal ganglia and cerebellar outputs in the pathogenesis of dystonia. Our results further suggest that frequency analysis of brain recordings during cyclic movements may be a useful tool for analysis of the presence of movement-related signals in various brain regions. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500435/ /pubmed/36158959 http://dx.doi.org/10.3389/fneur.2022.989340 Text en Copyright © 2022 Hernandez-Martin, Arguelles, Liker, Robison and Sanger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Neurology Hernandez-Martin, Estefania Arguelles, Enrique Liker, Mark Robison, Aaron Sanger, Terence D. Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
title | Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
title_full | Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
title_fullStr | Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
title_full_unstemmed | Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
title_short | Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
title_sort | increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia |
topic | Neurology |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500435/ https://www.ncbi.nlm.nih.gov/pubmed/36158959 http://dx.doi.org/10.3389/fneur.2022.989340 |
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