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Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia

The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, on...

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Autores principales: Hernandez-Martin, Estefania, Arguelles, Enrique, Liker, Mark, Robison, Aaron, Sanger, Terence D.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500435/
https://www.ncbi.nlm.nih.gov/pubmed/36158959
http://dx.doi.org/10.3389/fneur.2022.989340
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author Hernandez-Martin, Estefania
Arguelles, Enrique
Liker, Mark
Robison, Aaron
Sanger, Terence D.
author_facet Hernandez-Martin, Estefania
Arguelles, Enrique
Liker, Mark
Robison, Aaron
Sanger, Terence D.
author_sort Hernandez-Martin, Estefania
collection PubMed
description The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, one was undergoing testing for treatment of Tourette Syndrome and had neither dystonia nor abnormal movements during testing. Movement-related signals were evaluated by determining the magnitude of task-related frequency components. Brain signals were recorded in globus pallidus internus (GPi), the ventral oralis anterior/posterior (VoaVop) and the ventral intermediate (Vim) nuclei of the thalamus. In comparison to the subject without dystonia, both children with dystonia showed increased task-related activity in GPi and Vim. This finding is consistent with a role of both basal ganglia and cerebellar outputs in the pathogenesis of dystonia. Our results further suggest that frequency analysis of brain recordings during cyclic movements may be a useful tool for analysis of the presence of movement-related signals in various brain regions.
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spelling pubmed-95004352022-09-24 Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia Hernandez-Martin, Estefania Arguelles, Enrique Liker, Mark Robison, Aaron Sanger, Terence D. Front Neurol Neurology The contribution of different brain regions to movement abnormalities in children with dystonia is unknown. Three awake subjects undergoing depth electrode implantation for assessments of potential deep brain recording targets performed a rhythmic figure-8 drawing task. Two subjects had dystonia, one was undergoing testing for treatment of Tourette Syndrome and had neither dystonia nor abnormal movements during testing. Movement-related signals were evaluated by determining the magnitude of task-related frequency components. Brain signals were recorded in globus pallidus internus (GPi), the ventral oralis anterior/posterior (VoaVop) and the ventral intermediate (Vim) nuclei of the thalamus. In comparison to the subject without dystonia, both children with dystonia showed increased task-related activity in GPi and Vim. This finding is consistent with a role of both basal ganglia and cerebellar outputs in the pathogenesis of dystonia. Our results further suggest that frequency analysis of brain recordings during cyclic movements may be a useful tool for analysis of the presence of movement-related signals in various brain regions. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500435/ /pubmed/36158959 http://dx.doi.org/10.3389/fneur.2022.989340 Text en Copyright © 2022 Hernandez-Martin, Arguelles, Liker, Robison and Sanger. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neurology
Hernandez-Martin, Estefania
Arguelles, Enrique
Liker, Mark
Robison, Aaron
Sanger, Terence D.
Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
title Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
title_full Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
title_fullStr Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
title_full_unstemmed Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
title_short Increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
title_sort increased movement-related signals in both basal ganglia and cerebellar output pathways in two children with dystonia
topic Neurology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500435/
https://www.ncbi.nlm.nih.gov/pubmed/36158959
http://dx.doi.org/10.3389/fneur.2022.989340
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