Hydroxynonenal Causes Hepatocyte Death by Disrupting Lysosomal Integrity in Nonalcoholic Steatohepatitis

BACKGROUND & AIMS: The lipid oxidation is a key factor for damaging hepatocytes and causing cell death. However, the mechanisms underlying hepatocyte death and the role of the most popular lipid peroxidation product 4-hydroxy-2-nonenal (HNE) in nonalcoholic steatohepatitis (NASH) remains unclear...

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Detalles Bibliográficos
Autores principales: Seike, Takuya, Boontem, Piyakarn, Yanagi, Masahiro, Li, Shihui, Kido, Hidenori, Yamamiya, Daisuke, Nakagawa, Hidetoshi, Okada, Hikari, Yamashita, Tatsuya, Harada, Kenichi, Kikuchi, Mitsuru, Shiraishi, Yoshitake, Ozaki, Noriyuki, Kaneko, Shuichi, Yamashima, Tetsumori, Mizukoshi, Eishiro
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2022
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500440/
https://www.ncbi.nlm.nih.gov/pubmed/35787976
http://dx.doi.org/10.1016/j.jcmgh.2022.06.008

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