Cargando…

The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake

Previous findings in healthy humans suggest that selective serotonin reuptake inhibitors (SSRIs) modulate emotional processing via earlier changes in attention. However, many previous studies have provided inconsistent findings. One possible reason for such inconsistencies is that these studies did...

Descripción completa

Detalles Bibliográficos
Autores principales: Beinhölzl, Nathalie, Molloy, Eóin N., Zsido, Rachel G., Richter, Thalia, Piecha, Fabian A., Zheleva, Gergana, Scharrer, Ulrike, Regenthal, Ralf, Villringer, Arno, Okon-Singer, Hadas, Sacher, Julia
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500523/
https://www.ncbi.nlm.nih.gov/pubmed/36161146
http://dx.doi.org/10.3389/fnins.2022.809269
_version_ 1784795241537077248
author Beinhölzl, Nathalie
Molloy, Eóin N.
Zsido, Rachel G.
Richter, Thalia
Piecha, Fabian A.
Zheleva, Gergana
Scharrer, Ulrike
Regenthal, Ralf
Villringer, Arno
Okon-Singer, Hadas
Sacher, Julia
author_facet Beinhölzl, Nathalie
Molloy, Eóin N.
Zsido, Rachel G.
Richter, Thalia
Piecha, Fabian A.
Zheleva, Gergana
Scharrer, Ulrike
Regenthal, Ralf
Villringer, Arno
Okon-Singer, Hadas
Sacher, Julia
author_sort Beinhölzl, Nathalie
collection PubMed
description Previous findings in healthy humans suggest that selective serotonin reuptake inhibitors (SSRIs) modulate emotional processing via earlier changes in attention. However, many previous studies have provided inconsistent findings. One possible reason for such inconsistencies is that these studies did not control for the influence of either sex or sex hormone fluctuations. To address this inconsistency, we administered 20 mg escitalopram or placebo for seven consecutive days in a randomized, double-blind, placebo-controlled design to sixty healthy female participants with a minimum of 3 months oral contraceptive (OC) intake. Participants performed a modified version of an emotional flanker task before drug administration, after a single dose, after 1 week of SSRI intake, and after a 1-month wash-out period. Supported by Bayesian analyses, our results do not suggest a modulatory effect of escitalopram on behavioral measures of early attentional-emotional interaction in female individuals with regular OC use. While the specific conditions of our task may be a contributing factor, it is also possible that a practice effect in a healthy sample may mask the effects of escitalopram on the attentional-emotional interplay. Consequently, 1 week of escitalopram administration may not modulate attention toward negative emotional distractors outside the focus of attention in healthy female participants taking OCs. While further research in naturally cycling females and patient samples is needed, our results represent a valuable contribution toward the preclinical investigation of antidepressant treatment.
format Online
Article
Text
id pubmed-9500523
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-95005232022-09-24 The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake Beinhölzl, Nathalie Molloy, Eóin N. Zsido, Rachel G. Richter, Thalia Piecha, Fabian A. Zheleva, Gergana Scharrer, Ulrike Regenthal, Ralf Villringer, Arno Okon-Singer, Hadas Sacher, Julia Front Neurosci Neuroscience Previous findings in healthy humans suggest that selective serotonin reuptake inhibitors (SSRIs) modulate emotional processing via earlier changes in attention. However, many previous studies have provided inconsistent findings. One possible reason for such inconsistencies is that these studies did not control for the influence of either sex or sex hormone fluctuations. To address this inconsistency, we administered 20 mg escitalopram or placebo for seven consecutive days in a randomized, double-blind, placebo-controlled design to sixty healthy female participants with a minimum of 3 months oral contraceptive (OC) intake. Participants performed a modified version of an emotional flanker task before drug administration, after a single dose, after 1 week of SSRI intake, and after a 1-month wash-out period. Supported by Bayesian analyses, our results do not suggest a modulatory effect of escitalopram on behavioral measures of early attentional-emotional interaction in female individuals with regular OC use. While the specific conditions of our task may be a contributing factor, it is also possible that a practice effect in a healthy sample may mask the effects of escitalopram on the attentional-emotional interplay. Consequently, 1 week of escitalopram administration may not modulate attention toward negative emotional distractors outside the focus of attention in healthy female participants taking OCs. While further research in naturally cycling females and patient samples is needed, our results represent a valuable contribution toward the preclinical investigation of antidepressant treatment. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500523/ /pubmed/36161146 http://dx.doi.org/10.3389/fnins.2022.809269 Text en Copyright © 2022 Beinhölzl, Molloy, Zsido, Richter, Piecha, Zheleva, Scharrer, Regenthal, Villringer, Okon-Singer and Sacher. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Neuroscience
Beinhölzl, Nathalie
Molloy, Eóin N.
Zsido, Rachel G.
Richter, Thalia
Piecha, Fabian A.
Zheleva, Gergana
Scharrer, Ulrike
Regenthal, Ralf
Villringer, Arno
Okon-Singer, Hadas
Sacher, Julia
The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
title The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
title_full The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
title_fullStr The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
title_full_unstemmed The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
title_short The attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
title_sort attention-emotion interaction in healthy female participants on oral contraceptives during 1-week escitalopram intake
topic Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500523/
https://www.ncbi.nlm.nih.gov/pubmed/36161146
http://dx.doi.org/10.3389/fnins.2022.809269
work_keys_str_mv AT beinholzlnathalie theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT molloyeoinn theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT zsidorachelg theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT richterthalia theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT piechafabiana theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT zhelevagergana theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT scharrerulrike theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT regenthalralf theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT villringerarno theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT okonsingerhadas theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT sacherjulia theattentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT beinholzlnathalie attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT molloyeoinn attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT zsidorachelg attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT richterthalia attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT piechafabiana attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT zhelevagergana attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT scharrerulrike attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT regenthalralf attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT villringerarno attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT okonsingerhadas attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake
AT sacherjulia attentionemotioninteractioninhealthyfemaleparticipantsonoralcontraceptivesduring1weekescitalopramintake