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Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018)
BACKGROUND: Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adult...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2022
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500574/ https://www.ncbi.nlm.nih.gov/pubmed/36159291 http://dx.doi.org/10.3389/fpubh.2022.981749 |
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author | Zhang, Yangchang Liu, Weiwei Zhang, Wei Cheng, Rui Tan, Andi Shen, Shisi Xiong, Yang Zhao, Limei Lei, Xun |
author_facet | Zhang, Yangchang Liu, Weiwei Zhang, Wei Cheng, Rui Tan, Andi Shen, Shisi Xiong, Yang Zhao, Limei Lei, Xun |
author_sort | Zhang, Yangchang |
collection | PubMed |
description | BACKGROUND: Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the National Health and Nutrition Examination Survey (NHANES). METHODS: A total of 43,196 participants in the NHANES from 1999 to 2018 were included in the final analysis. Hyperlipidemia was determined based on the National Cholesterol Education Program guidelines. Blood Pb levels were assessed using inductively-coupled plasma mass spectrometry. Weighted multivariable logistic regression analysis and subgroup analysis were conducted to determine the correlation between blood Pb levels and hyperlipidemia. RESULTS: In the multivariable logistic regression model, high blood Pb levels were significantly associated with hyperlipidemia after adjusting for confounders (OR 1.41; 95%CI: 1.18–1.67). Furthermore, elevated blood Pb levels were associated with an increased risk of hyperlipidemia across the four quartile (Q) groups (Q1: OR 1.00; Q2: OR 1.16 [95%CI: 1.04–1.29]; Q3: OR 1.39 [95%CI: 1.21–1.59]; and Q4: OR 1.33 [95%CI: 1.15–1.54]; P for trend <0.05). Significant moderating effects were found in the subgroup analysis stratified by age, education, hypertension, and diabetes (P < 0.05). In sensitivity analysis, the ORs for hyperlipidemia across the quartiles of blood Pb levels were 1.00, 1.17 (95%CI: 1.05–1.30), 1.42 (95%CI: 1.24–1.62), and 1.38 (95%CI: 1.19–1.60) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after removing adults with arteriosclerotic cardiovascular disease, and the ORs were 1.00, 1.13 (95%CI: 1.01–1.25), 1.38 (95%CI: 1.21–1.56), and 1.32 (95%CI: 1.16–1.52) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after including pregnant women. CONCLUSION: The current study showed a positive association between blood lead levels and hyperlipidemia. |
format | Online Article Text |
id | pubmed-9500574 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-95005742022-09-24 Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) Zhang, Yangchang Liu, Weiwei Zhang, Wei Cheng, Rui Tan, Andi Shen, Shisi Xiong, Yang Zhao, Limei Lei, Xun Front Public Health Public Health BACKGROUND: Research on the association between blood lead (Pb) and lipid biomarkers have yielded inconsistent results, and epidemiological studies on blood Pb levels and hyperlipidemia are scarce. The present study aimed to examine the association between blood Pb levels and hyperlipidemia in adults from the National Health and Nutrition Examination Survey (NHANES). METHODS: A total of 43,196 participants in the NHANES from 1999 to 2018 were included in the final analysis. Hyperlipidemia was determined based on the National Cholesterol Education Program guidelines. Blood Pb levels were assessed using inductively-coupled plasma mass spectrometry. Weighted multivariable logistic regression analysis and subgroup analysis were conducted to determine the correlation between blood Pb levels and hyperlipidemia. RESULTS: In the multivariable logistic regression model, high blood Pb levels were significantly associated with hyperlipidemia after adjusting for confounders (OR 1.41; 95%CI: 1.18–1.67). Furthermore, elevated blood Pb levels were associated with an increased risk of hyperlipidemia across the four quartile (Q) groups (Q1: OR 1.00; Q2: OR 1.16 [95%CI: 1.04–1.29]; Q3: OR 1.39 [95%CI: 1.21–1.59]; and Q4: OR 1.33 [95%CI: 1.15–1.54]; P for trend <0.05). Significant moderating effects were found in the subgroup analysis stratified by age, education, hypertension, and diabetes (P < 0.05). In sensitivity analysis, the ORs for hyperlipidemia across the quartiles of blood Pb levels were 1.00, 1.17 (95%CI: 1.05–1.30), 1.42 (95%CI: 1.24–1.62), and 1.38 (95%CI: 1.19–1.60) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after removing adults with arteriosclerotic cardiovascular disease, and the ORs were 1.00, 1.13 (95%CI: 1.01–1.25), 1.38 (95%CI: 1.21–1.56), and 1.32 (95%CI: 1.16–1.52) for Q1, Q2, Q3, and Q4, respectively (P for trend <0.001) after including pregnant women. CONCLUSION: The current study showed a positive association between blood lead levels and hyperlipidemia. Frontiers Media S.A. 2022-09-09 /pmc/articles/PMC9500574/ /pubmed/36159291 http://dx.doi.org/10.3389/fpubh.2022.981749 Text en Copyright © 2022 Zhang, Liu, Zhang, Cheng, Tan, Shen, Xiong, Zhao and Lei. https://creativecommons.org/licenses/by/4.0/This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Public Health Zhang, Yangchang Liu, Weiwei Zhang, Wei Cheng, Rui Tan, Andi Shen, Shisi Xiong, Yang Zhao, Limei Lei, Xun Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) |
title | Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) |
title_full | Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) |
title_fullStr | Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) |
title_full_unstemmed | Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) |
title_short | Association between blood lead levels and hyperlipidemiais: Results from the NHANES (1999–2018) |
title_sort | association between blood lead levels and hyperlipidemiais: results from the nhanes (1999–2018) |
topic | Public Health |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500574/ https://www.ncbi.nlm.nih.gov/pubmed/36159291 http://dx.doi.org/10.3389/fpubh.2022.981749 |
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