Cargando…

Vemurafenib Inhibits Enterovirus A71 Genome Replication and Virus Assembly

Enterovirus A71 (EV-A71) infection is a major cause of hand, foot, and mouth disease (HFMD), which may be occasionally associated with severe neurological complications. There is currently a lack of treatment options for EV-A71 infection. The Raf-MEK-ERK signaling pathway, in addition to its critica...

Descripción completa

Detalles Bibliográficos
Autores principales:	Hu, Bodan, Chik, Kenn Ka-Heng, Chan, Jasper Fuk-Woo, Cai, Jian-Piao, Cao, Hehe, Tsang, Jessica Oi-Ling, Zou, Zijiao, Hung, Yin-Po, Tang, Kaiming, Jia, Lilong, Luo, Cuiting, Yin, Feifei, Ye, Zi-Wei, Chu, Hin, Yeung, Man-Lung, Yuan, Shuofeng
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500672/ https://www.ncbi.nlm.nih.gov/pubmed/36145288 http://dx.doi.org/10.3390/ph15091067

Ejemplares similares

1899. The Cellular Kinase Inhibitor OSU-03012 Inhibits Enterovirus 71 In Vitro
por: Chan, Jasper, et al.
Publicado: (2018)

Metabolic Profiling Reveals Significant Perturbations of Intracellular Glucose Homeostasis in Enterovirus-Infected Cells
por: Zou, Zijiao, et al.
Publicado: (2020)

Development of Three-Dimensional Human Intestinal Organoids as a Physiologically Relevant Model for Characterizing the Viral Replication Kinetics and Antiviral Susceptibility of Enteroviruses
por: Tsang, Jessica Oi-Ling, et al.
Publicado: (2021)

Lipidomic Profiling Reveals Significant Perturbations of Intracellular Lipid Homeostasis in Enterovirus-Infected Cells
por: Yan, Bingpeng, et al.
Publicado: (2019)

In silico structure-based discovery of a SARS-CoV-2 main protease inhibitor
por: Wen, Lei, et al.
Publicado: (2021)

The spike receptor-binding motif G496S substitution determines the replication fitness of SARS-CoV-2 Omicron sublineage
por: Liang, Ronghui, et al.
Publicado: (2022)

Broad-Spectrum Host-Based Antivirals Targeting the Interferon and Lipogenesis Pathways as Potential Treatment Options for the Pandemic Coronavirus Disease 2019 (COVID-19)
por: Yuan, Shuofeng, et al.
Publicado: (2020)

The celecoxib derivative kinase inhibitor AR-12 (OSU-03012) inhibits Zika virus via down-regulation of the PI3K/Akt pathway and protects Zika virus-infected A129 mice: A host-targeting treatment strategy
por: Chan, Jasper Fuk-Woo, et al.
Publicado: (2018)

hnRNP C modulates MERS-CoV and SARS-CoV-2 replication by governing the expression of a subset of circRNAs and cognitive mRNAs
por: Zhang, Xi, et al.
Publicado: (2022)

SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

Author Correction: SARS-CoV-2 infection induces inflammatory bone loss in golden Syrian hamsters
por: Qiao, Wei, et al.
Publicado: (2022)

918. Identification of novel druggable host targets for Middle East respiratory syndrome coronavirus using a quantitative phosphoproteomics approach
por: Chan, Jasper F W, et al.
Publicado: (2023)

Targeting SUMO Modification of the Non-Structural Protein 5 of Zika Virus as a Host-Targeting Antiviral Strategy
por: Zhu, Zheng, et al.
Publicado: (2019)

Cardiopulmonary failure in children infected with Enterovirus A71
por: Hsia, Shao-Hsuan, et al.
Publicado: (2020)

Screening of an FDA-Approved Drug Library with a Two-Tier System Identifies an Entry Inhibitor of Severe Fever with Thrombocytopenia Syndrome Virus
por: Yuan, Shuofeng, et al.
Publicado: (2019)

Phosphatidic acid phosphatase 1 impairs SARS-CoV-2 replication by affecting the glycerophospholipid metabolism pathway
por: Yan, Bingpeng, et al.
Publicado: (2022)

Severe fever with thrombocytopenia syndrome virus (SFTSV)-host interactome screen identifies viral nucleoprotein-associated host factors as potential antiviral targets
por: Cao, Jianli, et al.
Publicado: (2021)

Receptors for enterovirus 71
por: Yamayoshi, Seiya, et al.
Publicado: (2014)

Enterovirus 71 Outbreaks, Taiwan: Occurrence and Recognition
por: Lin, Tzou-Yien, et al.
Publicado: (2003)

Intranasal Boosting with Spike Fc-RBD of Wild-Type SARS-CoV-2 Induces Neutralizing Antibodies against Omicron Subvariants and Reduces Viral Load in the Nasal Turbinate of Mice
por: Cai, Jian-Piao, et al.
Publicado: (2023)

Targeting papain-like protease for broad-spectrum coronavirus inhibition
por: Yuan, Shuofeng, et al.
Publicado: (2022)

Enterovirus 71 Outbreak, Brunei
por: AbuBakar, Sazaly, et al.
Publicado: (2009)

Recombinant Human Enterovirus 71
Publicado: (2004)

The cellular receptor for enterovirus 71
por: Liu, Yue, et al.
Publicado: (2014)

Enterovirus 71 infection and vaccines
por: Yi, Eun-Je, et al.
Publicado: (2017)

Enterovirus A71 Vaccines
por: Li, Mei-Ling, et al.
Publicado: (2021)

Cell and tissue tropism of enterovirus 71 and other enteroviruses infections
por: Lin, Jing-Yi, et al.
Publicado: (2014)

Long-term psychiatric outcomes in youth with enterovirus A71 central nervous system involvement
por: Lin, Hsiang-Yuan, et al.
Publicado: (2022)

lncRNA expression signatures in response to enterovirus 71 infection
por: Yin, Zhixin, et al.
Publicado: (2013)

2642. Development of Human Intestinal Organoids as an Antiviral Evaluation Platform for Enteroviruses
por: Fuk-Woo Chan, Jasper, et al.
Publicado: (2019)

COPI Is Required for Enterovirus 71 Replication
por: Wang, Jianmin, et al.
Publicado: (2012)

Seroepidemiology of Human Enterovirus 71, Singapore
por: Ooi, Eng-Eong, et al.
Publicado: (2002)

Challenges to Licensure of Enterovirus 71 Vaccines
por: Lee, Min-Shi, et al.
Publicado: (2012)

112 The Development of Enterovirus 71 Vaccine
por: Xiuling, Li, et al.
Publicado: (2014)

Enterovirus 71 infection and neurological complications
por: Lee, Kyung Yeon
Publicado: (2016)

Antivirals and vaccines for Enterovirus A71
por: Lin, Jing-Yi, et al.
Publicado: (2019)

Cellular receptors for enterovirus A71
por: Kobayashi, Kyousuke, et al.
Publicado: (2020)

Adaptation and Virulence of Enterovirus-A71
por: Kobayashi, Kyousuke, et al.
Publicado: (2021)

Polymorphisms in enterovirus 71 receptors associated with susceptibility and clinical severity
por: Yen, Ting-Yu, et al.
Publicado: (2018)

Exosomes cloak the virion to transmit Enterovirus 71 non-lytically
por: Gu, Jiaqi, et al.
Publicado: (2019)

Cannot write session to /tmp/vufind_sessions/sess_np2h1fckkp1i3hbr19krgcig35