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Computation-Aided Design of Albumin Affibody-Inserted Antibody Fragment for the Prolonged Serum Half-Life

Single-chain variable fragments (scFvs) have been recognized as promising agents in cancer therapy. However, short serum half-life of scFvs often limits clinical application. Fusion to albumin affibody (ABD) is an effective and convenient half-life extension strategy. Although one terminus of scFv i...

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Detalles Bibliográficos
Autores principales:	Kwon, Na Hyun, Lee, Jae Hun, Kwon, Inchan
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500697/ https://www.ncbi.nlm.nih.gov/pubmed/36145517 http://dx.doi.org/10.3390/pharmaceutics14091769

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