In Silico Conformational Features of Botulinum Toxins A1 and E1 According to Intraluminal Acidification

Although botulinum neurotoxins (BoNTs) are among the most toxic compounds found in nature, their molecular mechanism of action is far from being elucidated. A key event is the conformational transition due to acidification of the interior of synaptic vesicles, leading to translocation of the BoNT ca...

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Detalles Bibliográficos
Autores principales: Cottone, Grazia, Chiodo, Letizia, Maragliano, Luca, Popoff, Michel-Robert, Rasetti-Escargueil, Christine, Lemichez, Emmanuel, Malliavin, Thérèse E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500700/
https://www.ncbi.nlm.nih.gov/pubmed/36136581
http://dx.doi.org/10.3390/toxins14090644

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500700/
https://www.ncbi.nlm.nih.gov/pubmed/36136581
http://dx.doi.org/10.3390/toxins14090644

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