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Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids

Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug pharmacophores into a single molecule. The hybrid...

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Autores principales: Singh, Ankit Kumar, Kumar, Adarsh, Singh, Harshwardhan, Sonawane, Pankaj, Paliwal, Harshali, Thareja, Suresh, Pathak, Prateek, Grishina, Maria, Jaremko, Mariusz, Emwas, Abdul-Hamid, Yadav, Jagat Pal, Verma, Amita, Khalilullah, Habibullah, Kumar, Pradeep
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500727/
https://www.ncbi.nlm.nih.gov/pubmed/36145292
http://dx.doi.org/10.3390/ph15091071
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author Singh, Ankit Kumar
Kumar, Adarsh
Singh, Harshwardhan
Sonawane, Pankaj
Paliwal, Harshali
Thareja, Suresh
Pathak, Prateek
Grishina, Maria
Jaremko, Mariusz
Emwas, Abdul-Hamid
Yadav, Jagat Pal
Verma, Amita
Khalilullah, Habibullah
Kumar, Pradeep
author_facet Singh, Ankit Kumar
Kumar, Adarsh
Singh, Harshwardhan
Sonawane, Pankaj
Paliwal, Harshali
Thareja, Suresh
Pathak, Prateek
Grishina, Maria
Jaremko, Mariusz
Emwas, Abdul-Hamid
Yadav, Jagat Pal
Verma, Amita
Khalilullah, Habibullah
Kumar, Pradeep
author_sort Singh, Ankit Kumar
collection PubMed
description Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug pharmacophores into a single molecule. The hybrid molecule acts through distinct modes of action on several targets at a given time with more efficacy and less susceptibility to resistance. Thus, there is a huge scope for using hybrid compounds to tackle the present difficulties in cancer medicine. Recent work has applied this technique to uncover some interesting molecules with substantial anticancer properties. In this study, we report data on numerous promising hybrid anti-proliferative/anti-tumor agents developed over the previous 10 years (2011–2021). It includes quinazoline, indole, carbazole, pyrimidine, quinoline, quinone, imidazole, selenium, platinum, hydroxamic acid, ferrocene, curcumin, triazole, benzimidazole, isatin, pyrrolo benzodiazepine (PBD), chalcone, coumarin, nitrogen mustard, pyrazole, and pyridine-based anticancer hybrids produced via molecular hybridization techniques. Overall, this review offers a clear indication of the potential benefits of merging pharmacophoric subunits from multiple different known chemical prototypes to produce more potent and precise hybrid compounds. This provides valuable knowledge for researchers working on complex diseases such as cancer.
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spelling pubmed-95007272022-09-24 Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids Singh, Ankit Kumar Kumar, Adarsh Singh, Harshwardhan Sonawane, Pankaj Paliwal, Harshali Thareja, Suresh Pathak, Prateek Grishina, Maria Jaremko, Mariusz Emwas, Abdul-Hamid Yadav, Jagat Pal Verma, Amita Khalilullah, Habibullah Kumar, Pradeep Pharmaceuticals (Basel) Review Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug pharmacophores into a single molecule. The hybrid molecule acts through distinct modes of action on several targets at a given time with more efficacy and less susceptibility to resistance. Thus, there is a huge scope for using hybrid compounds to tackle the present difficulties in cancer medicine. Recent work has applied this technique to uncover some interesting molecules with substantial anticancer properties. In this study, we report data on numerous promising hybrid anti-proliferative/anti-tumor agents developed over the previous 10 years (2011–2021). It includes quinazoline, indole, carbazole, pyrimidine, quinoline, quinone, imidazole, selenium, platinum, hydroxamic acid, ferrocene, curcumin, triazole, benzimidazole, isatin, pyrrolo benzodiazepine (PBD), chalcone, coumarin, nitrogen mustard, pyrazole, and pyridine-based anticancer hybrids produced via molecular hybridization techniques. Overall, this review offers a clear indication of the potential benefits of merging pharmacophoric subunits from multiple different known chemical prototypes to produce more potent and precise hybrid compounds. This provides valuable knowledge for researchers working on complex diseases such as cancer. MDPI 2022-08-28 /pmc/articles/PMC9500727/ /pubmed/36145292 http://dx.doi.org/10.3390/ph15091071 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Singh, Ankit Kumar
Kumar, Adarsh
Singh, Harshwardhan
Sonawane, Pankaj
Paliwal, Harshali
Thareja, Suresh
Pathak, Prateek
Grishina, Maria
Jaremko, Mariusz
Emwas, Abdul-Hamid
Yadav, Jagat Pal
Verma, Amita
Khalilullah, Habibullah
Kumar, Pradeep
Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
title Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
title_full Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
title_fullStr Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
title_full_unstemmed Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
title_short Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids
title_sort concept of hybrid drugs and recent advancements in anticancer hybrids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500727/
https://www.ncbi.nlm.nih.gov/pubmed/36145292
http://dx.doi.org/10.3390/ph15091071
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