Cargando…

Concept of Hybrid Drugs and Recent Advancements in Anticancer Hybrids

Cancer is a complex disease, and its treatment is a big challenge, with variable efficacy of conventional anticancer drugs. A two-drug cocktail hybrid approach is a potential strategy in recent drug discovery that involves the combination of two drug pharmacophores into a single molecule. The hybrid...

Descripción completa

Detalles Bibliográficos
Autores principales:	Singh, Ankit Kumar, Kumar, Adarsh, Singh, Harshwardhan, Sonawane, Pankaj, Paliwal, Harshali, Thareja, Suresh, Pathak, Prateek, Grishina, Maria, Jaremko, Mariusz, Emwas, Abdul-Hamid, Yadav, Jagat Pal, Verma, Amita, Khalilullah, Habibullah, Kumar, Pradeep
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2022
Materias:	Review
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500727/ https://www.ncbi.nlm.nih.gov/pubmed/36145292 http://dx.doi.org/10.3390/ph15091071

Ejemplares similares

Nitrogen Containing Heterocycles as Anticancer Agents: A Medicinal Chemistry Perspective
por: Kumar, Adarsh, et al.
Publicado: (2023)

Gaussian field-based 3D-QSAR and molecular simulation studies to design potent pyrimidine–sulfonamide hybrids as selective BRAF(V600E) inhibitors
por: Singh, Ankit Kumar, et al.
Publicado: (2022)

Challenges and Opportunities in the Crusade of BRAF Inhibitors: From 2002 to 2022
por: Singh, Ankit Kumar, et al.
Publicado: (2023)

Medicinal chemistry perspective of pyrido[2,3-d]pyrimidines as anticancer agents
por: Kumar, Adarsh, et al.
Publicado: (2023)

Guava Leaf Essential Oil as a Potent Antioxidant and Anticancer Agent: Validated through Experimental and Computational Study
por: Mandal, Ashok Kumar, et al.
Publicado: (2022)

Debelalactone Prevents Hepatic Cancer via Diminishing the Inflammatory Response and Oxidative Stress on Male Wistar Rats
por: Pathak, Prateek, et al.
Publicado: (2022)

In Silico Studies of Indole Derivatives as Antibacterial Agents
por: Shah, Mridul, et al.
Publicado: (2023)

Synthesis, Characterisation, and In Vitro Anticancer Activity of Curcumin Analogues Bearing Pyrazole/Pyrimidine Ring Targeting EGFR Tyrosine Kinase
por: Ahsan, Mohamed Jawed, et al.
Publicado: (2013)

Biological efficacy of novel metal complexes of Nitazoxanide: Synthesis, characterization, anti-COVID-19, antioxidant, antibacterial and anticancer activity studies
por: Sharfalddin, Abeer A., et al.
Publicado: (2022)

Investigating the Biological Potency of Nitazoxanide-Based Cu(II), Ni(II) and Zn(II) Complexes Synthesis, Characterization and Anti-COVID-19, Antioxidant, Antibacterial and Anticancer Activities
por: Sharfalddin, Abeer A., et al.
Publicado: (2023)

Synthesis, biological evaluation and in-silico ADME studies of novel series of thiazolidin-2,4-dione derivatives as antimicrobial, antioxidant and anticancer agents
por: Kumar, Harsh, et al.
Publicado: (2022)

Genetic Mechanisms for Hybrid Breeding in Vegetable Crops
por: Singh, Hira, et al.
Publicado: (2023)

In vitro Mechanistic Exploration of Novel Spiropyrrolidine Heterocyclic Hybrids as Anticancer Agents
por: Kumar, Raju Suresh, et al.
Publicado: (2020)

Prediction of anticancer molecules using hybrid model developed on molecules screened against NCI-60 cancer cell lines
por: Singh, Harinder, et al.
Publicado: (2016)

Compound-Specific 1D (1)H NMR Pulse Sequence Selection for Metabolomics Analyses
por: Singh, Upendra, et al.
Publicado: (2023)

Green Communication in Internet of Things: A Hybrid Bio-Inspired Intelligent Approach
por: Kumar, Manoj, et al.
Publicado: (2022)

Population Dynamics of Wide Compatibility System and Evaluation of Intersubspecific Hybrids by indica-japonica Hybridization in Rice
por: Kallugudi, Jayanth, et al.
Publicado: (2022)

In vitro and in silico evaluations of actinomycin X(2)and actinomycin D as potent anti-tuberculosis agents
por: Qureshi, Kamal Ahmad, et al.
Publicado: (2023)

Emergence of novel omicron hybrid variants: BA(x), XE, XD, XF more than just alphabets
por: Thakur, Pryanka, et al.
Publicado: (2022)

Special Issue “Hybrid Drugs: Design and Applications”
por: Singh, Parvesh, et al.
Publicado: (2023)

Alteration of Anticancer and Protein-Binding Properties of Gold(I) Alkynyl by Phenolic Schiff Bases Moieties
por: Babgi, Bandar A., et al.
Publicado: (2021)

High resolution mapping of QTLs for fruit color and firmness in Amrapali/Sensation mango hybrids
por: Srivastav, Manish, et al.
Publicado: (2023)

Single crystal, Hirshfeld surface and theoretical analysis of methyl 4-hydroxybenzoate, a common cosmetic, drug and food preservative—Experiment versus theory
por: Sharfalddin, Abeer, et al.
Publicado: (2020)

“Ayurveda management of Palmoplantar Psoriasis (Vipadika) -a case report”
por: Kumar Bhatted, Santosh, et al.
Publicado: (2023)

Tuning anticancer properties and DNA-binding of Pt(ii) complexes via alteration of nitrogen softness/basicity of tridentate ligands
por: Al-Rashdi, Kamelah S., et al.
Publicado: (2023)

Emergence of hybrid states of stem-like cancer cells correlates with poor prognosis in oral cancer
por: Vipparthi, Kavya, et al.
Publicado: (2022)

Molecular Insights into Therapeutic Potentials of Hybrid Compounds Targeting Alzheimer’s Disease
por: Jana, Ankit, et al.
Publicado: (2022)

A β–Sitosterol Encapsulated Biocompatible Alginate/Chitosan Polymer Nanocomposite for the Treatment of Breast Cancer
por: Afzal, Obaid, et al.
Publicado: (2022)

Lipoidal Soft Hybrid Biocarriers of Supramolecular Construction for Drug Delivery
por: Kumar, Dinesh, et al.
Publicado: (2012)

Synthesis, DFT Molecular Geometry and Anticancer Activity of Symmetrical 2,2′-(2-Oxo-1H-benzo[d]imidazole-1,3(2H)-diyl) Diacetate and Its Arylideneacetohydrazide Derivatives
por: Dhahri, Manel, et al.
Publicado: (2022)

Zika Virus Prediction Using AI-Driven Technology and Hybrid Optimization Algorithm in Healthcare
por: Dadheech, Pankaj, et al.
Publicado: (2022)

EAGA-MLP—An Enhanced and Adaptive Hybrid Classification Model for Diabetes Diagnosis
por: Mishra, Sushruta, et al.
Publicado: (2020)

Aggregation of biologically important peptides and proteins: inhibition or acceleration depending on protein and metal ion concentrations
por: Poulson, Benjamin Gabriel, et al.
Publicado: (2019)

Itaconic acid hybrids as potential anticancer agents
por: Perković, Ivana, et al.
Publicado: (2020)

Complexation of uranyl (UO(2))(2+) with bidentate ligands: XRD, spectroscopic, computational, and biological studies
por: Sharfalddin, Abeer A., et al.
Publicado: (2021)

Practical and Computational Studies of Bivalence Metal Complexes of Sulfaclozine and Biological Studies
por: Sharfalddin, Abeer A, et al.
Publicado: (2021)

Monocarbonyl Curcumin-Based Molecular Hybrids as Potent Antibacterial Agents
por: Singh, Atamjit, et al.
Publicado: (2019)

Fuzzy portfolio optimization: advances in hybrid multi-criteria methodologies
por: Gupta, Pankaj, et al.
Publicado: (2014)

Medical students’ perceptions of small group teaching effectiveness in hybrid curriculum
por: Sahu, Pradeep Kumar, et al.
Publicado: (2018)

Green synthesis, structural analysis and anticancer activity of dihydropyrimidinone derivatives
por: Dowarah, Jayanta, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_m8bdngpe1ulci66sr29rc379q7