Cargando…
Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man
Sarcomas in the head and neck area are rare diseases with an incidence of under 1% of all head and neck malignant tumours. Osteosarcomas or osteogenic sarcomas consist of neoplastic cells that produce osteoid bone or immature bone. Sarcomas develop more in the mandible than the maxilla. The exact di...
Autores principales: | , , , , , , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2022
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500801/ https://www.ncbi.nlm.nih.gov/pubmed/36143818 http://dx.doi.org/10.3390/medicina58091141 |
_version_ | 1784795311838855168 |
---|---|
author | Astl, Jaromír Belsan, Tomas Michnova, Ludmila Kubeš, Jiří Filipovsky, Tomas Blecha, Jiri Holy, Richard |
author_facet | Astl, Jaromír Belsan, Tomas Michnova, Ludmila Kubeš, Jiří Filipovsky, Tomas Blecha, Jiri Holy, Richard |
author_sort | Astl, Jaromír |
collection | PubMed |
description | Sarcomas in the head and neck area are rare diseases with an incidence of under 1% of all head and neck malignant tumours. Osteosarcomas or osteogenic sarcomas consist of neoplastic cells that produce osteoid bone or immature bone. Sarcomas develop more in the mandible than the maxilla. The exact diagnosis of different types of sarcomas is based on the immunohistochemical investigation. These rare tumours are of mesenchymal origin; osteosarcomas and chondrosarcomas are the most common types—Ewing’s sarcomas. The use of proton beam radiotherapy in the treatment of osteosarcoma of the maxilla is rarely reported in the literature. We present a case of successfully treated (surgery and proton beam radiotherapy) poorly differentiated highly aggressive osteosarcoma in the ethmoids and maxillary sinus and morbidity after the treatment. We were presented with a case of a 65-year-old man with anaesthesia and palsy of the right face. The stomatology department performed the extraction of a tooth. One month later, the wound was still open. The histology showed an osteogenic sarcoma in the area of the wound. The oncologist and maxillofacial surgeons in a catchment hospital recommended a nonsurgical approach. Hence, we performed a radical maxillectomy and ethmoidectomy, after which we continued with proton bean radiotherapy. The patient is now five years after therapy without signs of sarcoma; however, he has blindness in the right eye and reduced vision in the left eye, as well as gliosis of the brain, vertigo, tinnitus, trismus, and ancylostomiases. Head and neck osteosarcomas treatment is considered a complex multidisciplinary task. It is currently argued that there is no clear therapeutic protocol for successful treatment. Innovations in treatment modalities such as proton beam radiotherapy appear to have potential, although their effects on long-term morbidity and survival outcomes are still undetermined. We present a rare case report of an osteosarcoma of the maxilla involving an innovative, successful treatment procedure combining surgical excision followed by proton beam radiotherapy. This treatment approach may enable maximum tumour control. This protocol has not been adequately described in the world literature for this diagnosis. |
format | Online Article Text |
id | pubmed-9500801 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2022 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-95008012022-09-24 Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man Astl, Jaromír Belsan, Tomas Michnova, Ludmila Kubeš, Jiří Filipovsky, Tomas Blecha, Jiri Holy, Richard Medicina (Kaunas) Case Report Sarcomas in the head and neck area are rare diseases with an incidence of under 1% of all head and neck malignant tumours. Osteosarcomas or osteogenic sarcomas consist of neoplastic cells that produce osteoid bone or immature bone. Sarcomas develop more in the mandible than the maxilla. The exact diagnosis of different types of sarcomas is based on the immunohistochemical investigation. These rare tumours are of mesenchymal origin; osteosarcomas and chondrosarcomas are the most common types—Ewing’s sarcomas. The use of proton beam radiotherapy in the treatment of osteosarcoma of the maxilla is rarely reported in the literature. We present a case of successfully treated (surgery and proton beam radiotherapy) poorly differentiated highly aggressive osteosarcoma in the ethmoids and maxillary sinus and morbidity after the treatment. We were presented with a case of a 65-year-old man with anaesthesia and palsy of the right face. The stomatology department performed the extraction of a tooth. One month later, the wound was still open. The histology showed an osteogenic sarcoma in the area of the wound. The oncologist and maxillofacial surgeons in a catchment hospital recommended a nonsurgical approach. Hence, we performed a radical maxillectomy and ethmoidectomy, after which we continued with proton bean radiotherapy. The patient is now five years after therapy without signs of sarcoma; however, he has blindness in the right eye and reduced vision in the left eye, as well as gliosis of the brain, vertigo, tinnitus, trismus, and ancylostomiases. Head and neck osteosarcomas treatment is considered a complex multidisciplinary task. It is currently argued that there is no clear therapeutic protocol for successful treatment. Innovations in treatment modalities such as proton beam radiotherapy appear to have potential, although their effects on long-term morbidity and survival outcomes are still undetermined. We present a rare case report of an osteosarcoma of the maxilla involving an innovative, successful treatment procedure combining surgical excision followed by proton beam radiotherapy. This treatment approach may enable maximum tumour control. This protocol has not been adequately described in the world literature for this diagnosis. MDPI 2022-08-23 /pmc/articles/PMC9500801/ /pubmed/36143818 http://dx.doi.org/10.3390/medicina58091141 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Case Report Astl, Jaromír Belsan, Tomas Michnova, Ludmila Kubeš, Jiří Filipovsky, Tomas Blecha, Jiri Holy, Richard Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man |
title | Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man |
title_full | Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man |
title_fullStr | Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man |
title_full_unstemmed | Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man |
title_short | Highly Aggressive Osteosarcoma of the Ethmoids and Maxillary Sinus-A Case of Successful Surgery and Proton Beam Radiotherapy in a 65-Year-Old Man |
title_sort | highly aggressive osteosarcoma of the ethmoids and maxillary sinus-a case of successful surgery and proton beam radiotherapy in a 65-year-old man |
topic | Case Report |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500801/ https://www.ncbi.nlm.nih.gov/pubmed/36143818 http://dx.doi.org/10.3390/medicina58091141 |
work_keys_str_mv | AT astljaromir highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman AT belsantomas highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman AT michnovaludmila highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman AT kubesjiri highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman AT filipovskytomas highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman AT blechajiri highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman AT holyrichard highlyaggressiveosteosarcomaoftheethmoidsandmaxillarysinusacaseofsuccessfulsurgeryandprotonbeamradiotherapyina65yearoldman |