Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov

Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,...

Descripción completa

Detalles Bibliográficos
Autores principales: Pathompong, Paomephan, Pfütze, Sebastian, Surup, Frank, Boonpratuang, Thitiya, Choeyklin, Rattaket, Matasyoh, Josphat C., Decock, Cony, Stadler, Marc, Boonchird, Chuenchit
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500820/
https://www.ncbi.nlm.nih.gov/pubmed/36144704
http://dx.doi.org/10.3390/molecules27185968
_version_ 1784795316568981504
author Pathompong, Paomephan
Pfütze, Sebastian
Surup, Frank
Boonpratuang, Thitiya
Choeyklin, Rattaket
Matasyoh, Josphat C.
Decock, Cony
Stadler, Marc
Boonchird, Chuenchit
author_facet Pathompong, Paomephan
Pfütze, Sebastian
Surup, Frank
Boonpratuang, Thitiya
Choeyklin, Rattaket
Matasyoh, Josphat C.
Decock, Cony
Stadler, Marc
Boonchird, Chuenchit
author_sort Pathompong, Paomephan
collection PubMed
description Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities.
format Online
Article
Text
id pubmed-9500820
institution National Center for Biotechnology Information
language English
publishDate 2022
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-95008202022-09-24 Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov Pathompong, Paomephan Pfütze, Sebastian Surup, Frank Boonpratuang, Thitiya Choeyklin, Rattaket Matasyoh, Josphat C. Decock, Cony Stadler, Marc Boonchird, Chuenchit Molecules Article Five new drimane-type sesquiterpenoids were isolated from cultures of the tropical basidiomycetes, Perenniporia centrali-africana (originating from Kenya) and Cerrena sp. nov. (originating from Thailand). A new pereniporin A derivative (1), a new drimane-type sesquiterpene lactam (2), and the new 6,7-Dehydro-isodrimenediol (3) were isolated from P. centrali-africana. In parallel, the two new drimane-type sesquiterpene lactams 5 and 6 were isolated together with known isodrimenediol (4) from Cerrena sp. This is the first report of drimane-type sesquiterpene lactams from basidiomycetes. The structures were elucidated based on 1D and 2D nuclear magnetic resonance (NMR) spectroscopic data, in combination with high-resolution electrospray mass spectrometric (HR-ESIMS) data. The compounds were devoid of significant antimicrobial and cytotoxic activities. MDPI 2022-09-14 /pmc/articles/PMC9500820/ /pubmed/36144704 http://dx.doi.org/10.3390/molecules27185968 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pathompong, Paomephan
Pfütze, Sebastian
Surup, Frank
Boonpratuang, Thitiya
Choeyklin, Rattaket
Matasyoh, Josphat C.
Decock, Cony
Stadler, Marc
Boonchird, Chuenchit
Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
title Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
title_full Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
title_fullStr Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
title_full_unstemmed Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
title_short Drimane-Type Sesquiterpenoids Derived from the Tropical Basidiomycetes Perenniporia centrali-africana and Cerrena sp. nov
title_sort drimane-type sesquiterpenoids derived from the tropical basidiomycetes perenniporia centrali-africana and cerrena sp. nov
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500820/
https://www.ncbi.nlm.nih.gov/pubmed/36144704
http://dx.doi.org/10.3390/molecules27185968
work_keys_str_mv AT pathompongpaomephan drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT pfutzesebastian drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT surupfrank drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT boonpratuangthitiya drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT choeyklinrattaket drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT matasyohjosphatc drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT decockcony drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT stadlermarc drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov
AT boonchirdchuenchit drimanetypesesquiterpenoidsderivedfromthetropicalbasidiomycetesperenniporiacentraliafricanaandcerrenaspnov

Ejemplares similares