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Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer

Background: The predictive value of various systemic inflammatory parameters has been reported. However, it is still unclear which inflammatory parameters are the best predictors of prognosis in advanced gastric cancer and what are their mechanisms of action. The aim of this study was to evaluate th...

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Autores principales: Kim, Sung Gon, Eom, Bang Wool, Yoon, Hongman, Kim, Young-Woo, Ryu, Keun Won
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500881/
https://www.ncbi.nlm.nih.gov/pubmed/36142965
http://dx.doi.org/10.3390/jcm11185318
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author Kim, Sung Gon
Eom, Bang Wool
Yoon, Hongman
Kim, Young-Woo
Ryu, Keun Won
author_facet Kim, Sung Gon
Eom, Bang Wool
Yoon, Hongman
Kim, Young-Woo
Ryu, Keun Won
author_sort Kim, Sung Gon
collection PubMed
description Background: The predictive value of various systemic inflammatory parameters has been reported. However, it is still unclear which inflammatory parameters are the best predictors of prognosis in advanced gastric cancer and what are their mechanisms of action. The aim of this study was to evaluate the association between preoperative systemic inflammatory parameters and overall survival (OS) in patients with advanced gastric cancer. Methods: This retrospective study included 489 patients with stage II/III advanced gastric cancer treated at the National Cancer Center, Republic of Korea, between January 2012 and December 2015. We divided the patients into survivors and non-survivors and compared their clinicopathological characteristics. Univariate and multivariate analyses using the Cox proportional hazards model were performed to evaluate the prognostic value of inflammatory parameters. Results: The absolute lymphocyte count was significantly higher in survivors (2.07 ± 0.62 × 10(3)/µL vs. 1.88 ± 0.63 × 10(3)/µL, p = 0.001). The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were marginally lower in survivors. Survival analysis revealed that the NLR and PLR were independent prognostic factors for OS. Survival was significantly different depending on NLR and PLR in the same pathologic stages. Conclusions: NLR and PLR were independent prognostic factors for OS in patients with advanced gastric cancer. Regarding single inflammatory parameters, an elevated lymphocyte count was the only factor associated with a favorable prognosis. These results suggest that the enhanced immune function of patients affects their prognosis more than the increased systemic inflammatory response.
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spelling pubmed-95008812022-09-24 Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer Kim, Sung Gon Eom, Bang Wool Yoon, Hongman Kim, Young-Woo Ryu, Keun Won J Clin Med Article Background: The predictive value of various systemic inflammatory parameters has been reported. However, it is still unclear which inflammatory parameters are the best predictors of prognosis in advanced gastric cancer and what are their mechanisms of action. The aim of this study was to evaluate the association between preoperative systemic inflammatory parameters and overall survival (OS) in patients with advanced gastric cancer. Methods: This retrospective study included 489 patients with stage II/III advanced gastric cancer treated at the National Cancer Center, Republic of Korea, between January 2012 and December 2015. We divided the patients into survivors and non-survivors and compared their clinicopathological characteristics. Univariate and multivariate analyses using the Cox proportional hazards model were performed to evaluate the prognostic value of inflammatory parameters. Results: The absolute lymphocyte count was significantly higher in survivors (2.07 ± 0.62 × 10(3)/µL vs. 1.88 ± 0.63 × 10(3)/µL, p = 0.001). The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio (MLR), and platelet-to-lymphocyte ratio (PLR) were marginally lower in survivors. Survival analysis revealed that the NLR and PLR were independent prognostic factors for OS. Survival was significantly different depending on NLR and PLR in the same pathologic stages. Conclusions: NLR and PLR were independent prognostic factors for OS in patients with advanced gastric cancer. Regarding single inflammatory parameters, an elevated lymphocyte count was the only factor associated with a favorable prognosis. These results suggest that the enhanced immune function of patients affects their prognosis more than the increased systemic inflammatory response. MDPI 2022-09-09 /pmc/articles/PMC9500881/ /pubmed/36142965 http://dx.doi.org/10.3390/jcm11185318 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Kim, Sung Gon
Eom, Bang Wool
Yoon, Hongman
Kim, Young-Woo
Ryu, Keun Won
Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer
title Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer
title_full Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer
title_fullStr Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer
title_full_unstemmed Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer
title_short Prognostic Value of Preoperative Systemic Inflammatory Parameters in Advanced Gastric Cancer
title_sort prognostic value of preoperative systemic inflammatory parameters in advanced gastric cancer
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500881/
https://www.ncbi.nlm.nih.gov/pubmed/36142965
http://dx.doi.org/10.3390/jcm11185318
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