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Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral

Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously...

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Autores principales: Mohamed, Tarik A., Elshamy, Abdelsamed I., Abd El-Razek, Mohamed H., Abdel-Tawab, Asmaa M., Ali, Sherin K., Aboelmagd, Mohamed, Suenaga, Midori, Pare, Paul W., Umeyama, Akemi, Hegazy, Mohamed-Elamir F.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500913/
https://www.ncbi.nlm.nih.gov/pubmed/36144570
http://dx.doi.org/10.3390/molecules27185835
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author Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Abd El-Razek, Mohamed H.
Abdel-Tawab, Asmaa M.
Ali, Sherin K.
Aboelmagd, Mohamed
Suenaga, Midori
Pare, Paul W.
Umeyama, Akemi
Hegazy, Mohamed-Elamir F.
author_facet Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Abd El-Razek, Mohamed H.
Abdel-Tawab, Asmaa M.
Ali, Sherin K.
Aboelmagd, Mohamed
Suenaga, Midori
Pare, Paul W.
Umeyama, Akemi
Hegazy, Mohamed-Elamir F.
author_sort Mohamed, Tarik A.
collection PubMed
description Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F (1) and G (2), as well as four identified analogues (3–6) together with a furan derivate (7) were isolated from a solvent extract. Compounds were identified by spectroscopic techniques, including NMR, HREIMS, and CD, together with close spectral comparisons of previously published data. Sarcoconvolutum F (1) contains a rare 1-peroxid-15-hydroxy-10-ene functionality. Isolated metabolites (1–7) were screened against lung adenocarcinoma (A549), cervical cancer (HeLa) and oral cavity carcinoma (HSC-2) lines. Compound 4 exhibited an IC(50) 56 µM and 55 µM against A549 and HSC-2 cells, respectively.
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spelling pubmed-95009132022-09-24 Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral Mohamed, Tarik A. Elshamy, Abdelsamed I. Abd El-Razek, Mohamed H. Abdel-Tawab, Asmaa M. Ali, Sherin K. Aboelmagd, Mohamed Suenaga, Midori Pare, Paul W. Umeyama, Akemi Hegazy, Mohamed-Elamir F. Molecules Article Natural products and chemical analogues are widely used in drug discovery, notably in cancer and infectious disease pharmacotherapy. Sarcophyton convolutum (Alcyoniidae) a Red Sea–derived soft coral has been shown to be a rich source of macrocyclic diterpenes and cyclized derivatives. Two previously undescribed polyoxygenated cembrane-type diterpenoids, sarcoconvolutums F (1) and G (2), as well as four identified analogues (3–6) together with a furan derivate (7) were isolated from a solvent extract. Compounds were identified by spectroscopic techniques, including NMR, HREIMS, and CD, together with close spectral comparisons of previously published data. Sarcoconvolutum F (1) contains a rare 1-peroxid-15-hydroxy-10-ene functionality. Isolated metabolites (1–7) were screened against lung adenocarcinoma (A549), cervical cancer (HeLa) and oral cavity carcinoma (HSC-2) lines. Compound 4 exhibited an IC(50) 56 µM and 55 µM against A549 and HSC-2 cells, respectively. MDPI 2022-09-08 /pmc/articles/PMC9500913/ /pubmed/36144570 http://dx.doi.org/10.3390/molecules27185835 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Mohamed, Tarik A.
Elshamy, Abdelsamed I.
Abd El-Razek, Mohamed H.
Abdel-Tawab, Asmaa M.
Ali, Sherin K.
Aboelmagd, Mohamed
Suenaga, Midori
Pare, Paul W.
Umeyama, Akemi
Hegazy, Mohamed-Elamir F.
Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
title Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
title_full Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
title_fullStr Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
title_full_unstemmed Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
title_short Sarcoconvolutums F and G: Polyoxygenated Cembrane-Type Diterpenoids from Sarcophyton convolutum, a Red Sea Soft Coral
title_sort sarcoconvolutums f and g: polyoxygenated cembrane-type diterpenoids from sarcophyton convolutum, a red sea soft coral
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500913/
https://www.ncbi.nlm.nih.gov/pubmed/36144570
http://dx.doi.org/10.3390/molecules27185835
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