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Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke

During a stroke, a series of biochemical and metabolic changes occur which eventually lead to the death of cells by necrosis or apoptosis. This is a multi-stage process involving oxidative stress and an inflammatory response from the first signs of occlusion of a blood vessel until the late stages o...

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Autores principales: Pawluk, Hanna, Kołodziejska, Renata, Grześk, Grzegorz, Kozakiewicz, Mariusz, Woźniak, Alina, Pawluk, Mateusz, Kosinska, Agnieszka, Grześk, Magdalena, Wojtasik, Jakub, Kozera, Grzegorz
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2022
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500922/
https://www.ncbi.nlm.nih.gov/pubmed/36142524
http://dx.doi.org/10.3390/ijms231810614
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author Pawluk, Hanna
Kołodziejska, Renata
Grześk, Grzegorz
Kozakiewicz, Mariusz
Woźniak, Alina
Pawluk, Mateusz
Kosinska, Agnieszka
Grześk, Magdalena
Wojtasik, Jakub
Kozera, Grzegorz
author_facet Pawluk, Hanna
Kołodziejska, Renata
Grześk, Grzegorz
Kozakiewicz, Mariusz
Woźniak, Alina
Pawluk, Mateusz
Kosinska, Agnieszka
Grześk, Magdalena
Wojtasik, Jakub
Kozera, Grzegorz
author_sort Pawluk, Hanna
collection PubMed
description During a stroke, a series of biochemical and metabolic changes occur which eventually lead to the death of cells by necrosis or apoptosis. This is a multi-stage process involving oxidative stress and an inflammatory response from the first signs of occlusion of a blood vessel until the late stages of regeneration and healing of ischemic tissues. The purpose of the research was to assess the concentration of pro-inflammatory cytokines IL-6 and TNF-α in the blood serum of patients with ischemic stroke (AIS) and to investigate their role as new markers in predicting functional prognosis after thrombolytic therapy. The researches have shown that the concentrations of the measured biomarkers were higher compared to the control group. Serum levels of IL-6 and THF-α before the initiation of intravenous thrombolysis were lower in the subgroup of patients with a favourable functional result (mRS: 0–2 pts) compared to the group of patients with an unfavourable functional result (mRS: 3–6 pts). A positive correlation was found between the concentration of IL-6 and TNF-α in patients with AIS during <4.5 h and on one day after the onset of stroke, which means that the concentration of IL-6 increases with the increase in TNF-α concentration. It has also been shown that higher levels of IL-6 in the acute phase of stroke and on the first and seventh days, and TNF-α during onset, were associated with poorer early and late prognosis in patients treated with intravenous thrombolysis. A relationship was found between the level of IL-6 and TNF-α in the subacute AIS and the severity of the neurological deficit. It has been shown that the investigated biomarkers may be a prognostic factor in the treatment of thrombolytic AIS.
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spelling pubmed-95009222022-09-24 Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke Pawluk, Hanna Kołodziejska, Renata Grześk, Grzegorz Kozakiewicz, Mariusz Woźniak, Alina Pawluk, Mateusz Kosinska, Agnieszka Grześk, Magdalena Wojtasik, Jakub Kozera, Grzegorz Int J Mol Sci Article During a stroke, a series of biochemical and metabolic changes occur which eventually lead to the death of cells by necrosis or apoptosis. This is a multi-stage process involving oxidative stress and an inflammatory response from the first signs of occlusion of a blood vessel until the late stages of regeneration and healing of ischemic tissues. The purpose of the research was to assess the concentration of pro-inflammatory cytokines IL-6 and TNF-α in the blood serum of patients with ischemic stroke (AIS) and to investigate their role as new markers in predicting functional prognosis after thrombolytic therapy. The researches have shown that the concentrations of the measured biomarkers were higher compared to the control group. Serum levels of IL-6 and THF-α before the initiation of intravenous thrombolysis were lower in the subgroup of patients with a favourable functional result (mRS: 0–2 pts) compared to the group of patients with an unfavourable functional result (mRS: 3–6 pts). A positive correlation was found between the concentration of IL-6 and TNF-α in patients with AIS during <4.5 h and on one day after the onset of stroke, which means that the concentration of IL-6 increases with the increase in TNF-α concentration. It has also been shown that higher levels of IL-6 in the acute phase of stroke and on the first and seventh days, and TNF-α during onset, were associated with poorer early and late prognosis in patients treated with intravenous thrombolysis. A relationship was found between the level of IL-6 and TNF-α in the subacute AIS and the severity of the neurological deficit. It has been shown that the investigated biomarkers may be a prognostic factor in the treatment of thrombolytic AIS. MDPI 2022-09-13 /pmc/articles/PMC9500922/ /pubmed/36142524 http://dx.doi.org/10.3390/ijms231810614 Text en © 2022 by the authors. https://creativecommons.org/licenses/by/4.0/Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (https://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Pawluk, Hanna
Kołodziejska, Renata
Grześk, Grzegorz
Kozakiewicz, Mariusz
Woźniak, Alina
Pawluk, Mateusz
Kosinska, Agnieszka
Grześk, Magdalena
Wojtasik, Jakub
Kozera, Grzegorz
Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke
title Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke
title_full Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke
title_fullStr Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke
title_full_unstemmed Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke
title_short Selected Mediators of Inflammation in Patients with Acute Ischemic Stroke
title_sort selected mediators of inflammation in patients with acute ischemic stroke
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9500922/
https://www.ncbi.nlm.nih.gov/pubmed/36142524
http://dx.doi.org/10.3390/ijms231810614
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